舍曲林诱发帕金森症。一例病例报告及舍曲林对多巴胺代谢影响的体内研究。

Sertraline induced parkinsonism. A case report and an in-vivo study of the effect of sertraline on dopamine metabolism.

作者信息

Di Rocco A, Brannan T, Prikhojan A, Yahr M D

机构信息

The Mount Sinai Medical Center, Department of Neurology, New York, NY, USA.

出版信息

J Neural Transm (Vienna). 1998;105(2-3):247-51. doi: 10.1007/s007020050053.

DOI:10.1007/s007020050053

PMID:9660102

Abstract

We report a patient with a parkinsonian syndrome induced by sertraline (Zoloft), an SSRI antidepressant, whose symptoms resolved after the drug was discontinued. This case prompted us to investigate the effect of sertraline on dopamine metabolism in animals. Sertraline (30 mg/kg, i.p.) or placebo (vehicle) was administered to two groups of six normal, anesthetized rats and using cerebral microdyalisis extracellular striatal levels of dopamine, the dopamine metabolites (HVA and DOPAC), as well as the serotonin metabolite 5-HIIA were monitored. In animals pre-treated with sertraline, DOPAC, HVA, and 5-HIAA levels were significantly decreased compared to control animals (p < 0.01). These data indicate that sertraline has an effect on dopamine metabolism, which may alter function in the striatum and induce a parkinsonian syndrome.

摘要

我们报告了一例由选择性5-羟色胺再摄取抑制剂（SSRI）抗抑郁药舍曲林（左洛复）诱发帕金森综合征的患者，停药后其症状缓解。该病例促使我们研究舍曲林对动物多巴胺代谢的影响。将两组各6只正常麻醉大鼠分别给予舍曲林（30mg/kg，腹腔注射）或安慰剂（溶媒），并通过脑微透析监测细胞外纹状体多巴胺、多巴胺代谢产物（高香草酸和3,4-二羟基苯乙酸）以及5-羟吲哚乙酸水平。与对照动物相比，预先给予舍曲林的动物中，3,4-二羟基苯乙酸、高香草酸和5-羟吲哚乙酸水平显著降低（p<0.01）。这些数据表明舍曲林对多巴胺代谢有影响，这可能改变纹状体功能并诱发帕金森综合征。