Kapur V K, Sakalkale R P, Samuel K V, Meisheri I V, Bhagwat A D, Ramprasad A, Waingankar V S
Department of Pediatric Surgery, B.J. Wadia Hospital for Children, Parel, Bombay, India.
J Pediatr Surg. 1998 Jun;33(6):935-7. doi: 10.1016/s0022-3468(98)90678-9.
Nephroblastoma (Wilms' tumor) is the most common renal malignancy in childhood. Extrarenal Wilms' tumor is uncommon, and the diagnosis is almost always postsurgical. The authors report two cases, located in the sigmoid mesocolon, one of these having an associated horseshoe kidney. Both were treated with excision followed by chemotherapy. They are now 36 months and 7 months postchemotherapy, respectively, and are symptom and recurrence free. Both had favorable histological findings. Association with a horseshoe kidney raises an important issue regarding the histogenesis of these tumors. The authors believe that there is a nexus between the fusion of metanephric blastema during the sixth to seventh week of intrauterine life and the "ectopic" metanephric blastema cells that may give rise to extrarenal Wilms' tumor. Association with a horseshoe kidney with an extrarenal Wilms' tumor has been reported on five previous occasions. The authors closely examine the link between the two.
肾母细胞瘤（威尔姆斯瘤）是儿童期最常见的肾恶性肿瘤。肾外威尔姆斯瘤并不常见，诊断几乎总是在手术后做出。作者报告了两例位于乙状结肠系膜的病例，其中一例伴有马蹄肾。两例均接受了切除手术，随后进行化疗。目前，他们分别在化疗后36个月和7个月，均无症状且无复发。两例的组织学检查结果均良好。与马蹄肾相关联引发了关于这些肿瘤组织发生的一个重要问题。作者认为，在子宫内生命的第六至七周期间后肾胚基的融合与可能产生肾外威尔姆斯瘤的“异位”后肾胚基细胞之间存在联系。此前曾有五次报告称肾外威尔姆斯瘤与马蹄肾相关联。作者仔细研究了两者之间的联系。
