Bader G, Lejeune S, Messner M
Service de Pathologie et Chirurgie Buccale, UFR Odontologie, CHRU Rennes, France.
J Periodontol. 1998 Jun;69(6):729-32. doi: 10.1902/jop.1998.69.6.729.
During immunosuppression with cyclosporine, gingival overgrowth, a minor secondary effect, may appear in the first weeks of treatment. In certain cases it may affect the function and/or esthetic appearance in a manner intolerable to the patient. A new immunnosuppressive molecule, tacrolimus, presently used as a treatment of second choice to control acute corticoresistant rejection, may bring oral comfort to these patients, since it reduces gingival overgrowth to negligible levels.
在用环孢素进行免疫抑制治疗期间，牙龈增生作为一种轻微的副作用，可能在治疗的最初几周出现。在某些情况下，它可能会以患者无法忍受的方式影响功能和/或美观。一种新的免疫抑制分子他克莫司，目前作为控制急性皮质抵抗性排斥反应的二线治疗药物使用，可能会给这些患者带来口腔舒适感，因为它能将牙龈增生减少到可忽略不计的水平。
