Preston A M, Dowdy R P, Preston M A, Freeman J N
J Nutr. 1976 Oct;106(10):1391-7. doi: 10.1093/jn/106.10.1391.
The effects of feeding three levels of dietary chromium (Cr) to non-pregnant guinea pigs, guinea pigs during pregnancy and lactation and F-1 offspring guinea pigs on weight gain, glucose tolerance, glucose peak time value and serum cholesterol concentration has been investigated. Dietary levels of Cr were: Basal Diet (B) = 0.125 ppm; B supplemented with 0.5 ppm Cr (S1 Diet) and B supplemented with 50 ppm Cr (S2 Diet). All groups had similar weight gain patterns and daily feed intake levels. Parent generation guinea pigs fed the B diet consumed less than 10 mug Cr/kg body weight/day while F-U guinea pigs consumed more than this amount. Mortality rates during pregnancy were greater in guinea pigs fed the B diet than in the Cr supplemented groups suggesting a possible protective effect by Dr. Glucose tolerance, glucose peak time values and serum cholesterol appeared to be more affected by pregnancy and generation of guinea pigs than by the level of dietary Cr. Results suggest that species differences may exist between Cr requirements of guinea pigs and rodents for avoiding glucose tolerance.
研究了给未怀孕的豚鼠、怀孕和哺乳期的豚鼠以及F-1代豚鼠后代喂食三种不同水平的膳食铬（Cr）对体重增加、葡萄糖耐量、葡萄糖峰值时间值和血清胆固醇浓度的影响。膳食铬水平分别为：基础日粮（B）=0.125 ppm；添加0.5 ppm铬的基础日粮（S1日粮）和添加50 ppm铬的基础日粮（S2日粮）。所有组的体重增加模式和每日采食量水平相似。喂食B日粮的亲代豚鼠每天每千克体重摄入的铬少于10微克，而F-1代豚鼠摄入的铬超过这个量。喂食B日粮的豚鼠在怀孕期间的死亡率高于补充铬的组，这表明铬可能具有保护作用。葡萄糖耐量、葡萄糖峰值时间值和血清胆固醇似乎受豚鼠的怀孕和代际影响比受膳食铬水平的影响更大。结果表明，豚鼠和啮齿动物在避免葡萄糖耐量方面对铬的需求可能存在物种差异。
