Matin C M, Ostwald R
J Nutr. 1975 May;105(5):525-33. doi: 10.1093/jn/105.5.525.
Food intake and liveweight gain of 11 cholesterol-fed and 10 control guinea pigs were measured for 33 days to determine whether depressed growth previously observed in young guinea pigs fed cholesterol was due to decreased food intake or to reduced food utilization. The guinea pigs were fed a laboratory stock diet containing 5% cottonseed oil; 1% cholesterol was added to the diet for the experimental group. Results showed that food intake was significantly less in the cholesterol-fed group, while requirements for maintenance and for liveweight gain, as adjusted to metabolic body size (Wkg-0.75), were not significantly different. Food energy retention was estimated by comparing dry body weight and moisture, fat and protein content of two groups of four controls and four cholesterol-fed guinea pigs at the beginning and at the end of a 20-day food-intake period. Values derived for maintenance requirement in this comparative body composition study correlated well with those of the 33-day experiment. We conclude that feeding cholesterol to guinea pigs reduced food intake for unknown reasons but does not affect food utilization.
对11只喂食胆固醇的豚鼠和10只对照豚鼠的食物摄入量和体重增加情况进行了33天的测量，以确定先前在喂食胆固醇的幼年豚鼠中观察到的生长抑制是由于食物摄入量减少还是食物利用率降低所致。豚鼠喂食含有5%棉籽油的实验室常规饲料；实验组的饲料中添加了1%的胆固醇。结果表明，喂食胆固醇的组食物摄入量明显较少，而根据代谢体重（Wkg-0.75）调整后的维持和体重增加需求并无显著差异。通过比较两组各4只对照豚鼠和4只喂食胆固醇的豚鼠在20天食物摄入期开始和结束时的干体重、水分、脂肪和蛋白质含量，估算食物能量保留情况。在这项比较身体成分研究中得出的维持需求值与33天实验的值相关性良好。我们得出结论，给豚鼠喂食胆固醇会出于未知原因减少食物摄入量，但不会影响食物利用率。
