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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Physiol. 1976 Aug;260(1):37-44. doi: 10.1113/jphysiol.1976.sp011502.

The rate at which carbon monoxide displaces oxygen from its combination with haemoglobin in solution, has been measured spectrophotometrically, using a rapid-mixing stopped-flow technique. 2. In the presence of carbon dioxide, the reaction proceeds by a unimolecular dissociation, with a rate constant r. 3. The relationship of the reciprocal of r to the ratio PO2/PCO is non-linear, and a different curve is obtained at each carbon monoxide concentration. 4. From measurements of the rate constant at temperatures between 5 and 35 degrees C, it is concluded that the non-linearity is due to the formation at a finite rate of an intermediate complex, CO2Hb4O6, by the reaction of carbon dioxide with Hb4O6.

利用快速混合停流技术，通过分光光度法测定了一氧化碳在溶液中从与血红蛋白结合物中置换氧气的速率。2. 在二氧化碳存在的情况下，反应通过单分子解离进行，速率常数为r。3. r的倒数与PO2/PCO之比的关系是非线性的，并且在每个一氧化碳浓度下都得到不同的曲线。4. 通过在5至35摄氏度之间的温度下测量速率常数得出结论，这种非线性是由于二氧化碳与Hb4O6反应以有限速率形成中间复合物CO2Hb4O6所致。

J Physiol. 1976 Aug;260(1):37-44. doi: 10.1113/jphysiol.1976.sp011502.

The rate at which carbon monoxide displaces oxygen from its combination with haemoglobin in solution, has been measured spectrophotometrically, using a rapid-mixing stopped-flow technique. 2. In the presence of carbon dioxide, the reaction proceeds by a unimolecular dissociation, with a rate constant r. 3. The relationship of the reciprocal of r to the ratio PO2/PCO is non-linear, and a different curve is obtained at each carbon monoxide concentration. 4. From measurements of the rate constant at temperatures between 5 and 35 degrees C, it is concluded that the non-linearity is due to the formation at a finite rate of an intermediate complex, CO2Hb4O6, by the reaction of carbon dioxide with Hb4O6.

利用快速混合停流技术，通过分光光度法测定了一氧化碳在溶液中从与血红蛋白结合物中置换氧气的速率。2. 在二氧化碳存在的情况下，反应通过单分子解离进行，速率常数为r。3. r的倒数与PO2/PCO之比的关系是非线性的，并且在每个一氧化碳浓度下都得到不同的曲线。4. 通过在5至35摄氏度之间的温度下测量速率常数得出结论，这种非线性是由于二氧化碳与Hb4O6反应以有限速率形成中间复合物CO2Hb4O6所致。