Fallab-Stubi C L, Zellweger J P, Sauty A, Uldry C, Iorillo D, Burnier M
Policlinique Médicale Universitaire, Lausanne, Switzerland.
Int J Tuberc Lung Dis. 1998 Jul;2(7):525-30.
Non-adherence to treatment is a frequent problem in the preventive chemoprophylaxis of tuberculosis.
To evaluate the usefulness of the Medication Event Monitoring System (MEMS) for following and improving patient adherence to 6-month treatment with isoniazid.
Three methods of monitoring compliance, MEMS, pill count and a urine test for isoniazid, were compared prospectively in 30 patients. The efficacy of a combined intervention by the physician and the pharmacist was evaluated in non-compliant patients.
According to the MEMS data, overall adherence to isoniazid therapy was 91.5%, and 86% of the patients were considered compliant throughout the period of observation. The pill count and the urine test tended to overestimate the overall compliance when compared to the MEMS. The combined intervention of the physician and pharmacist allowed drug adherence to be enhanced in non-compliant patients, but the effect was only transient if this was not repeated every month.
Our results suggest that the MEMS system is a useful approach for monitoring and improving compliance with preventive chemotherapy for tuberculosis.
在结核病预防性化学预防中，不坚持治疗是一个常见问题。
评估用药事件监测系统（MEMS）在跟踪和提高患者对异烟肼6个月治疗的依从性方面的作用。
对30名患者前瞻性地比较了三种监测依从性的方法，即MEMS、清点药片和异烟肼尿液检测。对不依从患者评估了医生和药剂师联合干预的效果。
根据MEMS数据，异烟肼治疗的总体依从率为91.5%，86%的患者在整个观察期内被认为依从。与MEMS相比，清点药片和尿液检测往往高估了总体依从性。医生和药剂师的联合干预使不依从患者的药物依从性得到提高，但如果不是每月重复进行，效果只是短暂的。
我们的结果表明，MEMS系统是监测和提高结核病预防性化疗依从性的一种有用方法。
