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独居霉素诱导的黑色脂质膜电导的涨落与弛豫分析

Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes.

作者信息

Moore L E, Neher E

出版信息

J Membr Biol. 1976 Jun 30;27(4):347-62. doi: 10.1007/BF01869145.

DOI:10.1007/BF01869145
PMID:966263
Abstract

Fluctuation and relaxation analyses were performed on monazomycin-induced conductance of lipid bilayer membranes. With both methods a slow (sec) and a fast (msec) current component are apparent; however, the amplitude of the slow, voltage-dependent process is greater than that of the fast component in the step relaxation experiment and less in the fluctuation experiment. The fluctuation analysis showed principally a rapid voltage-dependent process which appears to be related to the multistate character of the conducting channel. The experimental results are interpreted in terms of a simplified kinetic model which is used to calculate relaxation and noise amplitudes.

摘要

对莫那霉素诱导的脂质双分子层膜电导进行了涨落和弛豫分析。两种方法都显示出一个慢(秒级)电流成分和一个快(毫秒级)电流成分;然而,在阶跃弛豫实验中,慢的、电压依赖性过程的幅度大于快成分的幅度,而在涨落实验中则较小。涨落分析主要显示出一个快速的电压依赖性过程,这似乎与导电通道的多态特性有关。实验结果根据一个简化的动力学模型进行解释,该模型用于计算弛豫和噪声幅度。

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Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes.独居霉素诱导的黑色脂质膜电导的涨落与弛豫分析
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引用本文的文献

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Alamethicin-induced conductances in lipid bilayers: I. Data analysis and simple steady-state model.
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J Membr Biol. 1981 Feb 28;58(3):161-74. doi: 10.1007/BF01870902.
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Electrical noise from lipid bilayer membranes in the presence of hydrophobic ions.存在疏水性离子时脂质双分子层膜产生的电噪声。
J Membr Biol. 1977 Dec 15;37(3-4):321-45. doi: 10.1007/BF01940938.

本文引用的文献

1
Studies of the conductance changes induced in bimolecular lipid membranes by alamethicin.研究短杆菌肽 A 诱导双分子脂质膜电导率变化。
J Membr Biol. 1972 Dec;7(1):325-44. doi: 10.1007/BF01867924.
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The statistical nature of the acetycholine potential and its molecular components.乙酰胆碱电位及其分子成分的统计学性质。
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Voltage-dependent conductance induced in thin lipid membranes by monazomycin.莫那霉素在薄脂质膜中诱导产生的电压依赖性电导。
4
Conductance noise of monazomycin-doped bilayer membranes.掺杂独居霉素的双层膜的电导噪声。
J Membr Biol. 1979 Apr 9;45(3-4):277-92. doi: 10.1007/BF01869289.
5
Decamethonium both opens and blocks endplate channels.十烃季铵既能打开又能阻断终板通道。
Proc Natl Acad Sci U S A. 1978 Jun;75(6):2994-8. doi: 10.1073/pnas.75.6.2994.
J Gen Physiol. 1972 Sep;60(3):263-84. doi: 10.1085/jgp.60.3.263.
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The unit conductance channel of alamethicin.阿拉霉素的单位电导通道。
Biochim Biophys Acta. 1972 Mar 17;255(3):1014-8. doi: 10.1016/0005-2736(72)90415-4.
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The nature of the voltage-dependent conductance induced by alamethicin in black lipid membranes.短杆菌肽A在黑色脂质膜中诱导产生的电压依赖性电导的性质。
J Membr Biol. 1973 Dec 31;14(2):143-76. doi: 10.1007/BF01868075.
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Membrane noise.膜噪声
Prog Biophys Mol Biol. 1974;28:189-265. doi: 10.1016/0079-6107(74)90019-4.
7
Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction.对乙酰胆碱在青蛙神经肌肉接头处产生的终板电流波动进行电压钳分析。
J Physiol. 1973 Dec;235(3):655-91. doi: 10.1113/jphysiol.1973.sp010410.
8
Relaxation spectra of potassium channel noise from squid axon membranes.来自鱿鱼轴突膜的钾通道噪声的弛豫谱。
Proc Natl Acad Sci U S A. 1973 Mar;70(3):876-9. doi: 10.1073/pnas.70.3.876.
9
Time-variant conductance of bilayer membranes treated with monazomycin and alamethicin.经莫那霉素和阿拉霉素处理的双层膜的时变电导
Proc Natl Acad Sci U S A. 1972 Dec;69(12):3742-4. doi: 10.1073/pnas.69.12.3742.
10
Statistical analysis of alamethicin channels in black lipid membranes.黑脂质膜中短杆菌肽通道的统计分析。
J Membr Biol. 1974;19(3):277-303. doi: 10.1007/BF01869983.