Chernokhvostova E V, Subbotina Iu L, Sukhoroslova L I
Zh Mikrobiol Epidemiol Immunobiol. 1978 Mar(3):97-9.
Specific IgA and sIgA antibodies were studied in the sera of patients suffering from various intestinal diseases (dysentery, salmonellosis, typhoid fever, chronic typhoid carrier state) and in the sera of healthy persons immunized by parenteral route with typhoid alcohol vaccine. The nature of antibodies was identified in Coombs' test, using monospecific antisera to alpha-chain and to the secretory component. IgA and sIgA antibodies were revealed most frequently in the sera of dysentery patients and of chronic typhoid carriers. No sIgA antibodies were found in the sera of subcutaneously immunized persons. The presence of specific sIgA antibodies in the serum reflects the participation of local immune mechanisms in the formation of systemic immunity in the intestinal infections.
对患有各种肠道疾病（痢疾、沙门氏菌病、伤寒、慢性伤寒带菌状态）患者的血清以及经肠道外途径接种伤寒酒精疫苗免疫的健康人的血清中的特异性IgA和sIgA抗体进行了研究。利用针对α链和分泌成分的单特异性抗血清，在库姆斯试验中鉴定了抗体的性质。在痢疾患者和慢性伤寒带菌者的血清中最常检测到IgA和sIgA抗体。在皮下免疫者的血清中未发现sIgA抗体。血清中特异性sIgA抗体的存在反映了局部免疫机制在肠道感染全身免疫形成中的参与。
