Klein B
INSERM U475, Montpellier, France.
Curr Opin Hematol. 1998 May;5(3):186-91. doi: 10.1097/00062752-199805000-00007.
Interleukin (IL)-6 plays a major role in the control of the survival and proliferation of myeloma cell lines and primary myeloma cells. The genes of the receptors of IL-6 have been cloned, and the major signaling pathways involved in gp130 IL-6 transducer activation have been identified. In addition, another five cytokines that activate the gp130 IL-6 transducer have been identified. We review the recent data on gp130 cytokines and gp130-mediated signal transduction, their involvement in myeloma cell biology, and we discuss the possible therapeutic applications of this knowledge.
白细胞介素（IL）-6在骨髓瘤细胞系和原发性骨髓瘤细胞的存活与增殖控制中发挥着主要作用。IL-6受体的基因已被克隆，并且已确定参与gp130 IL-6转导激活的主要信号通路。此外，还发现了另外五种激活gp130 IL-6转导器的细胞因子。我们综述了关于gp130细胞因子和gp130介导的信号转导的最新数据，它们在骨髓瘤细胞生物学中的作用，并讨论了这些知识可能的治疗应用。
