Hirano T, Nakajima K, Hibi M
Department of Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Japan.
Cytokine Growth Factor Rev. 1997 Dec;8(4):241-52. doi: 10.1016/s1359-6101(98)80005-1.
The interleukin-6 cytokine family plays roles in a wide variety of tissues and organs, including the immune hematopoietic and nervous systems. Gp130 is a signal-transducing subunit shared by the receptors for the IL-6 family of cytokines. The binding of a ligand to its receptor induces the dimerization of gp130, leading to the activation of JAK tyrosine kinase and tyrosine phosphorylation of gp130. These events lead to the activation of multiple signal-transduction pathways, such as the STAT, Ras-MAPK and PI-3 kinase pathways whose activation is controlled by distinct regions of gp130. We propose a model showing that the outcome of the signal transduction depends on the balance or interplay among the contradictory signal transduction pathways that are simultaneously generated through a cytokine receptor in a given target cell.
白细胞介素-6细胞因子家族在包括免疫造血系统和神经系统在内的多种组织和器官中发挥作用。Gp130是白细胞介素-6细胞因子家族受体共享的信号转导亚基。配体与其受体的结合诱导Gp130二聚化，导致JAK酪氨酸激酶激活和Gp130的酪氨酸磷酸化。这些事件导致多种信号转导途径的激活，如STAT、Ras-MAPK和PI-3激酶途径，其激活由Gp130的不同区域控制。我们提出了一个模型，表明信号转导的结果取决于通过给定靶细胞中的细胞因子受体同时产生的相互矛盾的信号转导途径之间的平衡或相互作用。
