Yokota S, Komatsu T, Yano K, Taki K, Shimada Y
Department of Anesthesiology, Nagoya University School of Medicine, Japan.
Nagoya J Med Sci. 1998 May;61(1-2):47-52.
Although oral clonidine premedication is known to reduce the hemodynamic response under general anesthesia, effects of the hemodynamic response during sedated fiberoptic nasal intubation have not yet been examined. Our aim was to compare the effects of clonidine premedication on hemodynamic responses with those of atropine and hydroxyzine premedication during sedated fiberoptic nasal intubation. Thirty adult patients were randomly assigned to one of two groups: Group 1 patients (n = 15) were premedicated with atropine sulfate (0.01 mg/kg) and hydroxyzine hydrochloride (1mg/kg) intramuscularly, and group 2 patients (n = 15) were premedicated with clonidine (5 micrograms/kg) orally. We compared the hemodynamic response and sedation level in fiberoptic nasal intubation between the two groups. there were no significant differences in sedation levels and postoperative complaints between the two groups. But the oral clonidine premedication (Group 2) blunted hemodynamic changes during the fiberoptic intubation. No profound hypotension or marked bradycardia was noted in group 2. We concluded that the oral clonidine premedication might contribute to hemodynamic stability during sedated fiberoptic nasal intubation.
尽管已知口服可乐定进行术前用药可减轻全身麻醉下的血流动力学反应，但尚未研究其在镇静纤维鼻插管期间对血流动力学反应的影响。我们的目的是比较可乐定术前用药与阿托品和羟嗪术前用药在镇静纤维鼻插管期间对血流动力学反应的影响。30例成年患者被随机分为两组：第1组患者（n = 15）肌肉注射硫酸阿托品（0.01 mg/kg）和盐酸羟嗪（1mg/kg）进行术前用药，第2组患者（n = 15）口服可乐定（5微克/千克）进行术前用药。我们比较了两组在纤维鼻插管时的血流动力学反应和镇静水平。两组之间的镇静水平和术后主诉无显著差异。但口服可乐定术前用药（第2组）减轻了纤维插管期间的血流动力学变化。第2组未观察到严重低血压或明显心动过缓。我们得出结论，口服可乐定术前用药可能有助于在镇静纤维鼻插管期间保持血流动力学稳定。
