Nishikawa T, Taguchi M, Kimura T, Taguchi N, Sato Y, Dai M
Department of Anesthesiology, University of Tsukuba.
Masui. 1991 Jul;40(7):1083-8.
The authors studied 30 patients undergoing general anesthesia in order to evaluate whether oral clonidine premedication could attenuate the hemodynamic changes associated with laryngoscopy and tracheal intubation. Patients were randomly assigned to one of two groups; clonidine group (n = 15) who received oral clonidine of approximately 5 micrograms.kg-1, or control group (n = 15) who received no clonidine. The magnitude of increases in mean blood pressure from baseline values following laryngoscopy and tracheal intubation in the clonidine group was significantly smaller as compared with that in the control group (20 +/- 12 vs. 31 +/- 14 mmHg, mean +/- SD, P less than 0.05). There was also a significant difference between the two groups in the incidence of systolic blood pressure increases above 180 mmHg following laryngoscopy and tracheal intubation (0% vs. 26%, P less than 0.05). However, no significant difference was noted between the two groups in the heart rate responses to laryngoscopy and tracheal intubation. It is concluded that oral clonidine of 5 micrograms.kg-1 as a preanesthetic medication could attenuate the pressor responses associated with laryngoscopy and tracheal intubation.
作者研究了30例接受全身麻醉的患者，以评估术前口服可乐定是否能减轻与喉镜检查及气管插管相关的血流动力学变化。患者被随机分为两组；可乐定组（n = 15）口服约5微克·千克-1的可乐定，或对照组（n = 15）未服用可乐定。与对照组相比，可乐定组喉镜检查及气管插管后平均血压较基线值升高的幅度显著更小（20±12 vs. 31±14 mmHg，均值±标准差，P<0.05）。两组在喉镜检查及气管插管后收缩压升高超过180 mmHg的发生率也存在显著差异（0% vs. 26%，P<0.05）。然而，两组在喉镜检查及气管插管时的心率反应方面未发现显著差异。结论是，5微克·千克-1的术前口服可乐定可减轻与喉镜检查及气管插管相关的升压反应。
