Chana J S, Grover R, Wilson G D, Hudson D A, Forders M, Sanders R, Grobbelaar A O
RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, Middlesex, UK.
Br J Plast Surg. 1998 Apr;51(3):191-4. doi: 10.1054/bjps.1997.0233.
Melanomas of the scalp are rare and have a poorer prognosis than melanomas arising at other cutaneous sites. In order to study the biology of this disease, the activity of the c-myc oncogene was studied in tumours from 25 patients with scalp melanoma using the technique of flow cytometry. Survival analysis revealed that stratification of patients according to oncogene activity provided a prognostic marker with shorter overall survival (log rank test, chi 2 = 3.9, P = 0.05) in tumours with high nuclear c-myc oncoprotein positivity. These results support our previous studies of the prognostic value of c-myc expression in melanoma and suggest that estimation of c-myc oncoprotein may be of clinical significance in identifying high risk patients.
头皮黑色素瘤较为罕见，其预后比发生于其他皮肤部位的黑色素瘤更差。为了研究该疾病的生物学特性，运用流式细胞术对25例头皮黑色素瘤患者肿瘤中的c-myc癌基因活性进行了研究。生存分析显示，根据癌基因活性对患者进行分层，可为高核c-myc癌蛋白阳性肿瘤的总生存期较短（对数秩检验，卡方 = 3.9，P = 0.05）提供一个预后标志物。这些结果支持了我们之前关于黑色素瘤中c-myc表达预后价值的研究，并表明c-myc癌蛋白的评估在识别高危患者方面可能具有临床意义。
