经睑内注射尿素治疗眼睑恶性肿瘤（作者译）
[Treatment of malignant lid tumours by intrapalpebral injection of urea (author's transl)].
作者信息
Freyler H, Nichorlis S, Egerer I, Ruge-Sauermann I
出版信息
Klin Monbl Augenheilkd. 1976 Jul;169(1):10-3.
36 malignant tumours of the eyelids (basaliomas, basal-cell carcinomas and squamous-cell carcinomas) have been treated by intrapalpebral injections of a 5% to 25% solution of urea as recommended by E.D. Danopoulos. 1.5 to 3.0 ml of the solutions were injected around the tumours twice per week. Six malignant tumours disappeared completely after a treatment of eleven months; their largest initial diameter averaged 0.53 cm. Considering the protracted treatment, the uncertainty of success, without histological examination of the excised scar tissue, and finally because of the low rate of verified success, injections of dissolved urea around malignant tumours of the eye lids cannot replace radical excision.
按照E.D. 达诺普洛斯的建议，对36例眼睑恶性肿瘤（基底细胞瘤、基底细胞癌和鳞状细胞癌）进行了睑内注射5%至25%尿素溶液的治疗。每周两次在肿瘤周围注射1.5至3.0毫升该溶液。经过11个月的治疗，6例恶性肿瘤完全消失；其最大初始直径平均为0.53厘米。考虑到治疗过程漫长、成功的不确定性（未对切除的瘢痕组织进行组织学检查），以及最终核实的成功率较低，在眼睑恶性肿瘤周围注射溶解的尿素无法替代根治性切除。
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