Ketonen L M
Department of Radiology, University of Texas Medical Branch at Galveston, Galveston, Texas 77555-0709, USA.
Neurol Clin. 1998 Aug;16(3):581-98. doi: 10.1016/s0733-8619(05)70082-7.
Age-related white matter injury has been recognized increasingly with the improvement of brain imaging technology. Arteriosclerosis and venous collagenosis, which occur with aging, result in a spectrum of white matter changes that range from periventricular to subcortical and deep white matter hyperintensities best seen on T2 weighted magnetic resonance imaging. These white matter changes are associated not only with aging, but with hypertension and silent infarctions. Loss of brain volume and accumulation of iron in putamen occur with normal, healthy aging. This article discusses the imaging appearance of healthy aging and pathological correlates of similar appearing alterations. The imaging findings of the most common neurodegenerative disorders, Alzheimer's and Parkinson's disease, are highlighted.
随着脑成像技术的改进，与年龄相关的白质损伤越来越受到认可。随着年龄增长出现的动脉硬化和静脉胶原化会导致一系列白质变化，从脑室周围到皮质下和深部白质高信号，在T2加权磁共振成像上最为明显。这些白质变化不仅与衰老有关，还与高血压和无症状性梗死有关。在正常健康衰老过程中，脑容量会减少，壳核中铁会蓄积。本文讨论了健康衰老的影像学表现以及类似表现改变的病理相关性。重点介绍了最常见的神经退行性疾病——阿尔茨海默病和帕金森病的影像学表现。
