三核苷酸重复DNA结构：源于动态DNA的动态突变

Trinucleotide repeat DNA structures: dynamic mutations from dynamic DNA.

作者信息

Pearson C E, Sinden R R

机构信息

Center for Genome Research, Institute of Biosciences and Technology, Texas A&M University, Houston 77030-3303, USA.

出版信息

Curr Opin Struct Biol. 1998 Jun;8(3):321-30. doi: 10.1016/s0959-440x(98)80065-1.

DOI:10.1016/s0959-440x(98)80065-1

PMID:9666328

Abstract

Models for the disease-associated expansion of (CTG)n.(CAG)n, (CGG)n.(CCG)n, and (GAA)n.(TTC)n trinucleotide repeats involve alternative DNA structures formed during DNA replication, repair and recombination. These repeat sequences are inherently flexible and can form a variety of hairpins, intramolecular triplexes, quadruplexes, and slipped-strand structures that may be important intermediates and result in their genetic instability.

摘要

与疾病相关的(CTG)n.(CAG)n、(CGG)n.(CCG)n和(GAA)n.(TTC)n三核苷酸重复序列扩增的模型涉及DNA复制、修复和重组过程中形成的替代DNA结构。这些重复序列本质上具有灵活性，可形成各种发夹结构、分子内三链体、四链体和滑链结构，这些结构可能是重要的中间体并导致其遗传不稳定性。