Oliveri R L, Sibilia G, Valentino P, Russo C, Romeo N, Quattrone A
Institute of Neurology, Faculty of Medicine in Catanzaro, Italy.
Acta Neurol Scand. 1998 Jun;97(6):366-9. doi: 10.1111/j.1600-0404.1998.tb05967.x.
Chronic administration of corticosteroids has been reported to selectively impair explicit memory in systemic diseases without central nervous system involvement. Our aim was to verify that a short course of pulsed intravenous methylprednisolone (IVMP) administered for the treatment of a relapse impairs cognitive functions in relapsing-remitting multiple sclerosis (RRMS) patients and to determine whether this impairment is reversible.
Neuropsychological evaluations were made before the start of treatment, and 7 and 60 days after the end of treatment in 14 RRMS patients. The neuropsychological battery was also administered to 12 controls matched for age, sex and years of education.
RRMS patients performed worse than the controls at their baseline evaluation for a variety of neuropsychological tasks. IVMP administration induced a selective impairment of explicit memory which completely recovered 60 days after treatment.
In RRMS patients, IVMP induces a selective and reversible impairment of explicit memory.
据报道，长期使用皮质类固醇会选择性损害无中枢神经系统受累的全身性疾病中的外显记忆。我们的目的是验证用于治疗复发的短期脉冲静脉注射甲基强的松龙（IVMP）是否会损害复发缓解型多发性硬化症（RRMS）患者的认知功能，并确定这种损害是否可逆。
对14例RRMS患者在治疗开始前、治疗结束后7天和60天进行神经心理学评估。还对12名年龄、性别和受教育年限相匹配的对照者进行了神经心理测试。
在基线评估中，RRMS患者在各种神经心理学任务上的表现比对照组差。IVMP给药导致外显记忆的选择性损害，治疗60天后完全恢复。
在RRMS患者中，IVMP会导致外显记忆的选择性和可逆性损害。
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