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本文引用的文献

1
Safety of liquid intravenous immunoglobulin for neuroimmunologic disorders in the home setting: a retrospective analysis of 1085 infusions.家庭环境中静脉注射液体免疫球蛋白治疗神经免疫性疾病的安全性:1085次输注的回顾性分析
J Clin Neuromuscul Dis. 2008 Dec;10(2):52-5. doi: 10.1097/CND.0b013e31818b2aef.
2
Multiple sclerosis.多发性硬化症
Lancet. 2008 Oct 25;372(9648):1502-17. doi: 10.1016/S0140-6736(08)61620-7.
3
EFNS guidelines for the use of intravenous immunoglobulin in treatment of neurological diseases: EFNS task force on the use of intravenous immunoglobulin in treatment of neurological diseases.欧洲神经病学学会(EFNS)关于静脉注射免疫球蛋白治疗神经疾病的指南:欧洲神经病学学会静脉注射免疫球蛋白治疗神经疾病特别工作组
Eur J Neurol. 2008 Sep;15(9):893-908. doi: 10.1111/j.1468-1331.2008.02246.x.
4
B cells and multiple sclerosis.B细胞与多发性硬化症
Lancet Neurol. 2008 Sep;7(9):852-8. doi: 10.1016/S1474-4422(08)70192-3.
5
Oral prednisone taper following intravenous steroids fails to improve disability or recovery from relapses in multiple sclerosis.在多发性硬化症中,静脉注射类固醇后逐渐减少口服泼尼松并不能改善残疾状况或复发后的恢复情况。
Eur J Neurol. 2008 Jul;15(7):677-80. doi: 10.1111/j.1468-1331.2008.02146.x. Epub 2008 May 6.
6
Corticosteroids for multiple sclerosis: I. Application for treating exacerbations.用于治疗多发性硬化症的皮质类固醇:I. 治疗病情加重的应用。
Neurotherapeutics. 2007 Oct;4(4):618-26. doi: 10.1016/j.nurt.2007.07.008.
7
Plasma exchange therapy for steroid-refractory superimposed relapses in secondary progressive multiple sclerosis.血浆置换疗法用于继发进展型多发性硬化症中对类固醇难治的叠加复发情况。
J Neurol. 2007 Sep;254(9):1288-9. doi: 10.1007/s00415-006-0497-0. Epub 2007 Aug 16.
8
Natalizumab for multiple sclerosis.那他珠单抗用于治疗多发性硬化症。
N Engl J Med. 2007 Jun 21;356(25):2622-9. doi: 10.1056/NEJMct071462.
9
Myelin regeneration in demyelinating disorders: new developments in biology and clinical pathology.脱髓鞘疾病中的髓鞘再生:生物学与临床病理学的新进展
Curr Opin Neurol. 2007 Jun;20(3):294-8. doi: 10.1097/WCO.0b013e32813aee7f.
10
The incomplete nature of multiple sclerosis relapse resolution.多发性硬化症复发缓解的不完全性。
J Neurol Sci. 2007 May 15;256 Suppl 1:S14-8. doi: 10.1016/j.jns.2007.01.062. Epub 2007 Mar 2.

多发性硬化急性加重期的管理。

Management of acute exacerbations in multiple sclerosis.

作者信息

Ontaneda Daniel, Rae-Grant Alex D

机构信息

Neurological Institute, Cleveland Clinic, Cleveland, Ohio, 44195 USA.

出版信息

Ann Indian Acad Neurol. 2009 Oct;12(4):264-72. doi: 10.4103/0972-2327.58283.

DOI:10.4103/0972-2327.58283
PMID:20182574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2824954/
Abstract

A key component of multiple sclerosis is the occurrence of episodes of clinical worsening with either new symptoms or an increase in older symptoms over a few days or weeks. These are known as exacerbations of multiple sclerosis. In this review, we summarize the pathophysiology and treatment of exacerbations and describe how they are related to the overall management of this disease.

摘要

多发性硬化症的一个关键组成部分是在几天或几周内出现临床症状恶化的发作,伴有新症状或原有症状加重。这些被称为多发性硬化症的发作。在本综述中,我们总结了发作的病理生理学和治疗方法,并描述了它们与该疾病整体管理的关系。