Shirtcliffe P, Cameron E, Nicholson K G, Wiselka M J
Department of Infection and Tropical Medicine, Leicester Royal Infirmary.
J R Coll Physicians Lond. 1998 May-Jun;32(3):235-7.
Dengue virus infection is an increasingly important cause of imported fever, but many cases remain unrecognised. This study reviews the clinical features of dengue fever in patients seen at a regional department of infection and tropical medicine.
All patients with dengue fever presenting to the Department of Infection and Tropical Medicine in Leicester over a three year period.
The diagnosis of dengue fever was confirmed in 15 patients. The age range of patients was 19-61 years, and 80% were immigrants returning from a visit to their country of origin. In 11 (73%) patients, infection was associated with travel to India; others had gone to South-east Asia, Barbados and Uganda. All patients presented within three weeks of their return to the United Kingdom. The clinical manifestations of infection were often non-specific. They included fever, nausea, headache, cough and diarrhoea; 5 (33%) patients had a macular rash. Thrombocytopenia was seen in 7 (47%) patients, but only one had evidence of dengue haemorrhagic fever. Dengue infection was confirmed by serology in 14 (93%) patients. In one, dengue virus type 1 was identified by polymerase chain reaction, and the virus was subsequently isolated in tissue culture.
Dengue virus infection should be considered in all febrile travellers who have recently returned from areas where the disease is endemic and in whom tests for malaria are negative.
登革病毒感染是输入性发热日益重要的病因，但许多病例仍未被识别。本研究回顾了在某地区感染与热带医学科就诊的登革热患者的临床特征。
在三年期间内，所有到莱斯特感染与热带医学科就诊的登革热患者。
确诊登革热的患者有15例。患者年龄范围为19至61岁，80%为从原籍国探亲归来的移民。11例（73%）患者的感染与前往印度旅行有关；其他患者前往了东南亚、巴巴多斯和乌干达。所有患者在返回英国后的三周内就诊。感染的临床表现通常不具特异性。包括发热、恶心、头痛、咳嗽和腹泻；5例（33%）患者出现斑疹。7例（47%）患者出现血小板减少，但只有1例有登革出血热的证据。14例（93%）患者通过血清学确诊为登革病毒感染。1例通过聚合酶链反应鉴定出1型登革病毒，随后该病毒在组织培养中被分离出来。
对于所有近期从登革热流行地区归来且疟疾检测呈阴性的发热旅行者，均应考虑登革病毒感染。
