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创伤后应激障碍的心理神经内分泌学

Psychoneuroendocrinology of post-traumatic stress disorder.

作者信息

Yehuda R

机构信息

Posttraumatic Stress Disorder Program, Mount Sinai School of Medicine, Bronx Veterans Affairs, New York, New York, USA.

出版信息

Psychiatr Clin North Am. 1998 Jun;21(2):359-79. doi: 10.1016/s0193-953x(05)70010-1.

DOI:10.1016/s0193-953x(05)70010-1
PMID:9670231
Abstract

In 1980, the diagnosis of post-traumatic stress disorder (PTSD) was established to describe the long-lasting symptoms that can occur following exposure to extremely stressful life events. This article reviews the findings of neuroendocrinologic alterations in PTSD and summarizes the finding of hypothalamic-pituitary-adrenal (HPA), catecholamine, hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) systems. These are the neuroendocrine systems that have been studied in PTSD. Also included is a review of the basic facts about PTSD and biologic data.

摘要

1980年，创伤后应激障碍（PTSD）的诊断得以确立，用于描述在经历极端应激性生活事件后可能出现的长期症状。本文回顾了创伤后应激障碍神经内分泌改变的研究结果，并总结了下丘脑 - 垂体 - 肾上腺（HPA）、儿茶酚胺、下丘脑 - 垂体 - 甲状腺（HPT）和下丘脑 - 垂体 - 性腺（HPG）系统的研究结果。这些是在创伤后应激障碍中得到研究的神经内分泌系统。本文还包括对创伤后应激障碍基本事实和生物学数据的综述。

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