Peeters H, Van Gestel S, Vlietinck R, Derom C, Derom R
Center for Human Genetics, Katholieke Universiteit Leuven, Belgium.
Behav Genet. 1998 May;28(3):159-63. doi: 10.1023/a:1021416112215.
The aim of this study was to validate a zygosity questionnaire that can be administered over the telephone. Mothers of same-sexed twins of known zygosity and chronicity between 2 and 31 years of age were interviewed on a nine-item questionnaire. From the answers one unweighted and four weighted indices were computed. As single questions, the mother's opinion and the "two peas in a pod" question differentiated best between monozygotic and dizygotic twins. One independent well-trained observer assessed the zygosity based on the questionnaire and made the correct diagnosis in 96% of the cases. A weighted index of eight similarity questions yielded an accuracy of 98%. This study shows that the zygosity of same-sexed twins more than 2 years old and without gross physical malformation can reliably be determined by a telephone questionnaire with a high accuracy.
本研究的目的是验证一种可通过电话进行的合子性问卷。对年龄在2至31岁之间、已知合子性和出生时间的同性双胞胎的母亲进行了一项包含九个项目的问卷调查。根据答案计算出一个未加权指数和四个加权指数。作为单一问题，母亲的看法和“长得一模一样”问题在区分单卵双胞胎和双卵双胞胎方面表现最佳。一名经过良好培训的独立观察者根据问卷评估合子性，在96%的病例中做出了正确诊断。八个相似性问题的加权指数准确率为98%。这项研究表明，对于两岁以上且无明显身体畸形的同性双胞胎，通过电话问卷可以可靠且高精度地确定其合子性。
