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[急性髓系白血病诊断中细胞化学标准的评估]

[The evaluation of cytochemical criteria in the diagnosis of acute myeloid leukemia].

作者信息

Lohins'kyĭ V O, Vyhovs'ka Ia I, Tsymbaliuk I P, Masliak Z V, Mazurok A A

出版信息

Lik Sprava. 1998 Mar-Apr(2):54-8.

PMID:9670656
Abstract

With the purpose of determining the reliability of cytochemical parameters in the diagnosis of acute myeloid leukemia (AML) we carried out morphological and cytochemical studies on blast cells from 72 patients with freshly diagnosed AML. Cases were categorized according to the FAB-classification. It is recommended that a reaction to chloracetat-transferase be included into the set of cytochemical tests together with semiquantification of myeloperoxidase activity in blasts. Such an approach will, we believe, help in distinguishing between the M1/M2 and M4/M5 subvarieties of AML.

摘要

为了确定细胞化学参数在急性髓系白血病(AML)诊断中的可靠性,我们对72例新诊断的AML患者的原始细胞进行了形态学和细胞化学研究。病例根据FAB分类法进行分类。建议将氯乙酸酯酶反应与原始细胞中髓过氧化物酶活性的半定量分析一起纳入细胞化学检测项目中。我们认为,这种方法将有助于区分AML的M1/M2和M4/M5亚型。

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