Smishchuk Iu O
Lik Sprava. 1998 Mar-Apr(2):169-72.
Morphofunctional state was studied of intestinal enteroendocrine cells in biopsies obtained during fibrocolonoscopy using Grimelius's argyrophil reaction, as was immune status, condition of vegetative nervous system, together with the psychological examination being conducted. Most of the systems examined showed alterations peculiar to the stage of resistance of the general-adaptation syndrome. Dependence was found out between the morphofunctional state of endocrinocytes and type of disorder in the motor function of the intestine, parameters characterizing the vegetative regulation. Statistical analysis of the results obtained showed that most of the studied parameters of different systems have come in a single-modal distribution of variants (sequences), which fact suggests that pathologic processes in irritable colon syndrome (ICS) and chronic non-infectious undefined colitis (ChNIUC) might be uniform. Based on the above results the authors believe ICS and ChNIUC to be different stages of the same pathologic process. It can be asserted, to the authors' thinking, that ICS and ChNIUC are dystrophic, disregenerative, rather than inflammatory processes, as to their pathogenetic mechanisms.
利用格里米利厄斯嗜银反应，对纤维结肠镜检查时获取的活检组织中肠道肠内分泌细胞的形态功能状态进行了研究，同时还研究了免疫状态、自主神经系统状况，并进行了心理检查。所检查的大多数系统均显示出一般适应综合征抵抗阶段特有的改变。发现内分泌细胞的形态功能状态与肠道运动功能障碍类型、表征自主调节的参数之间存在相关性。对所得结果的统计分析表明，不同系统的大多数研究参数呈现出单一模式的变量分布（序列），这一事实表明，肠易激综合征（ICS）和慢性非感染性未定型结肠炎（ChNIUC）中的病理过程可能是一致的。基于上述结果，作者认为ICS和ChNIUC是同一病理过程的不同阶段。作者认为，可以断言，就其发病机制而言，ICS和ChNIUC是营养不良、再生障碍性的过程，而非炎症过程。
