Smishchuk Iu O
Lik Sprava. 1998 Jun(4):93-6.
The author proceeds from the belief that it is the dystrophic changes and disturbances in the regeneration of the intestinal epithelium that play a decisive role in the pathogenesis and morphogenesis of irritable intestinal syndrome and chronic non-infectious undefined colitis. The above alterations develop secondary to the action of harmful factors and disturbed trophic influences of neurohumoral systems of regulation during different stages of stress. At the same time the synthetic leu-enkefalin dalargin is endowed with a marked antistressor activity as well as ability to strikingly improve the regeneration of the epithelium. This was reason why therapeutic efficacy of dalargin has been given a trial in the above pathologies. Positive dynamics of symptoms of the conditions in question has been shown as well as of the histologic picture of colonic mucosa biopsies during the course of treatment of the above ailments with dalargin.
作者基于这样一种信念展开研究，即肠道上皮的营养不良性变化和再生紊乱在肠易激综合征和慢性非感染性未定型结肠炎的发病机制和形态发生中起决定性作用。上述改变是在应激的不同阶段，有害因素的作用以及神经体液调节系统营养影响紊乱继发产生的。同时，合成亮氨酸脑啡肽达乐argin具有显著的抗应激活性以及显著改善上皮再生的能力。这就是为什么在上述疾病中对达乐argin的治疗效果进行试验的原因。在用达乐argin治疗上述疾病的过程中，所涉病症的症状以及结肠黏膜活检的组织学图像均呈现出积极的动态变化。
