Hladka O A, Motyka O I
Lviv Scientific Research Institute of Epidemiology and Hygiene, Ukraine.
Mikrobiol Z. 1998 Mar-Apr;60(2):60-4.
The model of buccal epithelium of healthy people was used to study the effect of antibiotics with different action mechanism (benzylpenicillin, ampicylin, erythromycin, streptomycin) on the adhesion intensity of diphtheria corynebacteria. It has been established that only erythromycin in minimum inhibiting concentration manifested the ability to inhibit the adhesion of different biovars of Corynebacterium diphtheriae. The drug action did not depend on the level of adhesive activity of certain cultures. Subinhibiting concentrations of erythromycin did not affect the processes of the diphtheria corynebacteria adhesion.
采用健康人的颊黏膜上皮模型，研究具有不同作用机制的抗生素（苄青霉素、氨苄青霉素、红霉素、链霉素）对白喉棒状杆菌黏附强度的影响。已证实，只有最低抑菌浓度的红霉素表现出抑制不同生物型白喉棒状杆菌黏附的能力。药物作用不取决于某些培养物的黏附活性水平。亚抑菌浓度的红霉素不影响白喉棒状杆菌的黏附过程。
