Paliĭ G K, Neporada V P, Volianskiĭ I L
Antibiotiki. 1975 Feb;20(2):135-8.
The results of the study of the detoxicating effect of decamethoxin on diphtheria toxin are presented. It was noted that decamethoxin in subbacteriostatic concentrations inhibited the process of the toxin production in Corynebacteria diphtheriae. The detoxicating effect of the drug was clearly evident when used in a concentration of 10gamma/ml at a 2-hour exposure. Decamethoxin in a dose of 0.1 gamma/ml neutralized the effect of the diphtheria toxin on contact for 24 hours.
本文介绍了十甲季铵对白喉毒素解毒作用的研究结果。值得注意的是,低于抑菌浓度的十甲季铵可抑制白喉棒状杆菌产生毒素的过程。当以10微克/毫升的浓度作用2小时时,该药物的解毒作用明显。剂量为0.1微克/毫升的十甲季铵可在接触24小时内中和白喉毒素的作用。