一种对裂殖酵母分化起负调控作用的RNA结合蛋白。
An RNA binding protein negatively controlling differentiation in fission yeast.
作者信息
Tsukahara K, Yamamoto H, Okayama H
机构信息
Department of Biochemistry and Molecular Biology, The University of Tokyo Graduate School of Medicine, Bunkyo-ku, Tokyo 113, Japan.
出版信息
Mol Cell Biol. 1998 Aug;18(8):4488-98. doi: 10.1128/MCB.18.8.4488.
Abstract
The fission yeast Schizosaccharomyces pombe starts sexual development when starved for nutrients and simultaneously activated by mating pheromones. We have identified a new gene regulating the onset of this process. This gene, called nrd1(+), encodes a typical RNA binding protein that preferentially binds poly(U). Deletion of nrd1(+) causes cells to initiate sexual development without nutrient starvation. We have found that the biological role of nrd1(+) is to block the onset of sexual development by repressing the Ste11-regulated genes essential for conjugation and meiosis until cells reach a critical level of starvation.
摘要
裂殖酵母粟酒裂殖酵母在缺乏营养并同时被交配信息素激活时开始有性发育。我们鉴定出了一个调控这一过程起始的新基因。这个名为nrd1(+)的基因编码一种典型的RNA结合蛋白，该蛋白优先结合聚尿嘧啶。nrd1(+)的缺失会导致细胞在没有营养饥饿的情况下启动有性发育。我们发现nrd1(+)的生物学作用是通过抑制对细胞融合和减数分裂至关重要的、受Ste11调控的基因，来阻止有性发育的起始，直到细胞达到临界饥饿水平。
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