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采用章鱼法非体外循环冠状动脉旁路移植术:首批100例患者的结果

Coronary artery bypass grafting without cardiopulmonary bypass using the octopus method: results in the first one hundred patients.

作者信息

Jansen E W, Borst C, Lahpor J R, Gründeman P F, Eefting F D, Nierich A, Robles de Medina E O, Bredée J J

机构信息

Heart-Lung Institute, Department of Cardiopulmonary Surgery, Utrecht University Hospital, The Netherlands.

出版信息

J Thorac Cardiovasc Surg. 1998 Jul;116(1):60-7. doi: 10.1016/S0022-5223(98)70243-0.

Abstract

OBJECTIVE

Cardiopulmonary bypass and global cardiac arrest enable safe coronary artery bypass grafting but have adverse effects. In off-pump coronary bypass grafting, invasiveness is reduced, but anastomosis suturing is jeopardized by cardiac motion. Therefore the key to successful off-pump coronary bypass grafting is effective local cardiac wall stabilization.

METHODS

We prospectively assessed the safety and efficacy of the Octopus tissue stabilizer (Medtronic, Inc., Minneapolis, Minn.) in the first 100 patients selected for off-pump coronary bypass via full or limited surgical access. To immobilize and expose the coronary artery, two suction paddles (-400 mm Hg), fixed to the operating table-rail by an articulating arm, stabilized the anastomosis site.

RESULTS

One hundred forty-one grafts (96% arterial) were used to create 172 anastomoses (17% side-to-side), up to 4 per patient, on average 23 in the full access group (46 patients) and 1.2 in the limited access group (54 patients). Complications included conversion to cardiopulmonary bypass (2%), conversion from limited to full access (3%), myocardial infarction (4%), predischarge coronary reintervention (2%), and late coronary reintervention (1%). Median postoperative length of hospital stay was 4 days (limited access) or 5 days (full access). Rapid recovery allowed 96% of patients to resume social activities within 1 month. At the 6-month angiographic follow-up, 95% of anastomoses was patent. At the 2- to 22-month follow-up (mean, 13 months), 98 patients were in Canadian Cardiovascular Society class I and 2 patients were in class II.

CONCLUSION

These results suggest that off-pump coronary artery bypass grafting with the Octopus tissue stabilizer is safe. Early clinical outcome and patency rates warrant a randomized study comparing this methods with conventional coronary bypass grafting.

摘要

目的

体外循环和全心停搏可使冠状动脉旁路移植术安全进行,但存在不良影响。在非体外循环冠状动脉旁路移植术中,创伤性降低,但心脏运动危及吻合口缝合。因此,非体外循环冠状动脉旁路移植术成功的关键是有效的局部心脏壁稳定。

方法

我们前瞻性评估了章鱼组织稳定器(美敦力公司,明尼阿波利斯,明尼苏达州)在首批100例经完全或有限手术入路选择进行非体外循环冠状动脉旁路移植术患者中的安全性和有效性。为了固定并暴露冠状动脉,通过一个关节臂固定在手术台导轨上的两个吸引板(-400 mmHg)稳定了吻合部位。

结果

共使用141根移植物(96%为动脉移植物)进行了172处吻合(17%为侧侧吻合),每位患者最多4处,完全入路组(46例患者)平均23处,有限入路组(54例患者)平均1.2处。并发症包括转为体外循环(2%)、从有限入路转为完全入路(3%)、心肌梗死(4%)、出院前冠状动脉再次干预(2%)和晚期冠状动脉再次干预(1%)。术后住院时间中位数为4天(有限入路)或5天(完全入路)。快速康复使96%的患者在1个月内恢复社交活动。在6个月的血管造影随访中,95%的吻合口通畅。在2至22个月的随访(平均13个月)中,98例患者为加拿大心血管学会I级,2例患者为II级。

结论

这些结果表明,使用章鱼组织稳定器进行非体外循环冠状动脉旁路移植术是安全的。早期临床结果和通畅率值得进行一项随机研究,将该方法与传统冠状动脉旁路移植术进行比较。

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