多发性硬化症患者中T2病变体积与磁化传递比率直方图分析以及萎缩与病变负荷测量的比较。

Comparison of T2 lesion volume and magnetization transfer ratio histogram analysis and of atrophy and measures of lesion burden in patients with multiple sclerosis.

作者信息

Phillips M D, Grossman R I, Miki Y, Wei L, Kolson D L, van Buchem M A, Polansky M, McGowan J C, Udupa J K

机构信息

Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.

出版信息

AJNR Am J Neuroradiol. 1998 Jun-Jul;19(6):1055-60.

PMID:9672011

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8338648/

Abstract

PURPOSE

The purpose of this study was twofold: first, to compare two different measures of lesion burden in patients with multiple sclerosis (MS), the magnetization transfer ratio (MTR) histogram and T2 lesion volume; and, second, to investigate the relationship between lesion burden and atrophy in patients with MS.

METHODS

Thirty patients with MS were examined with MR imaging, including fast spin-echo T2- and proton density-weighted sequences as well as magnetization transfer sequences. The lesion burden in each subject was quantitated by MTR histographic analysis and by a computer-based method for calculating the total volume of lesions on T2-weighted images. Additionally, the CSF volume, the brain parenchymal volume, and the percentage of brain parenchymal volume were determined in all patients by using this method and were compared with measurements in eight control subjects.

RESULTS

Significant loss of parenchymal volume was seen in patients with MS as determined by increased CSF volume and decreased percentage of brain parenchymal volume relative to that in age-matched control subjects. An inverse correlation was observed between the peak height of the MTR histogram and T2 lesion volume. T2 lesion volume corresponded positively with CSF volume and inversely with percentage of brain parenchymal volume. The peak height of the MTR histogram corresponded positively with percentage of brain parenchymal volume and inversely with CSF volume.

CONCLUSION

MS patients sustain a significant loss of parenchymal volume (atrophy), which corresponds strongly with increasing lesion burden. T2 lesion volume and peak height of the MTR histogram show good correlation, and the peak height of the MTR histogram shows a superior correlation with measures of brain atrophy as compared with measurements of T2 lesion volume, suggesting that the MTR histogram may be a better indicator of global disease burden than is T2 lesion volume.

摘要

目的

本研究有两个目的：第一，比较多发性硬化症（MS）患者两种不同的病灶负荷测量方法，即磁化传递率（MTR）直方图和T2病灶体积；第二，研究MS患者病灶负荷与萎缩之间的关系。

方法

对30例MS患者进行磁共振成像检查，包括快速自旋回波T2加权和质子密度加权序列以及磁化传递序列。通过MTR组织学分析和基于计算机的方法计算T2加权图像上病灶的总体积，对每个受试者的病灶负荷进行定量。此外，使用该方法测定所有患者的脑脊液体积、脑实质体积和脑实质体积百分比，并与8名对照受试者的测量结果进行比较。