Phillips M D, Grossman R I, Miki Y, Wei L, Kolson D L, van Buchem M A, Polansky M, McGowan J C, Udupa J K
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
AJNR Am J Neuroradiol. 1998 Jun-Jul;19(6):1055-60.
The purpose of this study was twofold: first, to compare two different measures of lesion burden in patients with multiple sclerosis (MS), the magnetization transfer ratio (MTR) histogram and T2 lesion volume; and, second, to investigate the relationship between lesion burden and atrophy in patients with MS.
Thirty patients with MS were examined with MR imaging, including fast spin-echo T2- and proton density-weighted sequences as well as magnetization transfer sequences. The lesion burden in each subject was quantitated by MTR histographic analysis and by a computer-based method for calculating the total volume of lesions on T2-weighted images. Additionally, the CSF volume, the brain parenchymal volume, and the percentage of brain parenchymal volume were determined in all patients by using this method and were compared with measurements in eight control subjects.
Significant loss of parenchymal volume was seen in patients with MS as determined by increased CSF volume and decreased percentage of brain parenchymal volume relative to that in age-matched control subjects. An inverse correlation was observed between the peak height of the MTR histogram and T2 lesion volume. T2 lesion volume corresponded positively with CSF volume and inversely with percentage of brain parenchymal volume. The peak height of the MTR histogram corresponded positively with percentage of brain parenchymal volume and inversely with CSF volume.
MS patients sustain a significant loss of parenchymal volume (atrophy), which corresponds strongly with increasing lesion burden. T2 lesion volume and peak height of the MTR histogram show good correlation, and the peak height of the MTR histogram shows a superior correlation with measures of brain atrophy as compared with measurements of T2 lesion volume, suggesting that the MTR histogram may be a better indicator of global disease burden than is T2 lesion volume.
本研究有两个目的：第一，比较多发性硬化症（MS）患者两种不同的病灶负荷测量方法，即磁化传递率（MTR）直方图和T2病灶体积；第二，研究MS患者病灶负荷与萎缩之间的关系。
对30例MS患者进行磁共振成像检查，包括快速自旋回波T2加权和质子密度加权序列以及磁化传递序列。通过MTR组织学分析和基于计算机的方法计算T2加权图像上病灶的总体积，对每个受试者的病灶负荷进行定量。此外，使用该方法测定所有患者的脑脊液体积、脑实质体积和脑实质体积百分比，并与8名对照受试者的测量结果进行比较。
与年龄匹配的对照受试者相比，MS患者的脑实质体积明显减少，表现为脑脊液体积增加和脑实质体积百分比降低。观察到MTR直方图的峰值高度与T2病灶体积呈负相关。T2病灶体积与脑脊液体积呈正相关，与脑实质体积百分比呈负相关。MTR直方图的峰值高度与脑实质体积百分比呈正相关，与脑脊液体积呈负相关。
MS患者脑实质体积显著减少（萎缩），这与病灶负荷增加密切相关。T2病灶体积与MTR直方图的峰值高度显示出良好的相关性，并且与T2病灶体积测量相比，MTR直方图的峰值高度与脑萎缩测量显示出更好的相关性，这表明MTR直方图可能比T2病灶体积更能反映整体疾病负担。
