Okano A, Hajiro K, Takakuwa H, Kobashi Y
Department of Gastroenterology, Tenri Hospital, Nara, Japan.
Am J Gastroenterol. 1998 Jul;93(7):1144-5. doi: 10.1111/j.1572-0241.1998.00348.x.
Fibrolamellar carcinoma (FLC) of the liver is a rare variant of hepatocellular carcinoma (HCC), and only 13 cases have been reported in Japan up to 1997. We described a histologically unusual case of FLC. A 52-yr-old man was admitted to our hospital for work-up of hepatic mass. Laboratory examinations revealed no abnormalities except elevated serum alpha-fetoprotein (AFP) (2098 ng/ml). A diagnosis of HCC was made by imaging findings, and left lobectomy of the liver was performed. Histologically, the tumor was composed of areas of FLC mixed with ordinary HCC and those of pure ordinary HCC. Staining for AFP was positive in the HCC component and negative in the FLC component. Some cases of such mixed tumors have been reported in Europe and the United States, but not in Japan. We regarded our case as the first of the mixed tumor in Japan.
肝纤维板层癌(FLC)是肝细胞癌(HCC)的一种罕见变体,截至1997年,日本仅报告了13例。我们描述了1例组织学上不寻常的FLC病例。一名52岁男性因肝脏肿块检查入院。实验室检查除血清甲胎蛋白(AFP)升高(2098 ng/ml)外无异常。根据影像学检查结果诊断为HCC,并进行了肝左叶切除术。组织学上,肿瘤由FLC区域与普通HCC区域以及纯普通HCC区域混合组成。AFP染色在HCC成分中呈阳性,在FLC成分中呈阴性。欧美已报道过一些此类混合肿瘤病例,但日本尚未见报道。我们认为我们的病例是日本首例混合肿瘤。