Sutoo D, Akiyama K, Matsui A
Department of Pediatrics, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
Neurosci Lett. 1998 Jun 12;249(1):9-12. doi: 10.1016/s0304-3940(98)00309-7.
Stress ulceration of the stomach in mice was investigated from the aspect of the calcium/calmodulin-dependent dopamine synthesizing system in the brain. Cold stress was induced in mice by restraining them at 4 degrees C. Serum and brain calcium levels were increased by cold stress, and an increased brain calcium level was found to enhance dopamine synthesis and a successively increased brain dopamine level induced gastric ulcer formation. Development of gastric ulcers elicited by cold stress was significantly decreased by i.p. pretreatment with EDTA (1 micromol/mouse, 1 h before restraint) or alpha-methyltyrosine (a tyrosine hydroxylase inhibitor, 100 mg/kg, 24 h before restraint), and was further significantly increased by pretreatment with CaCl2 (40 micromol/kg, 1 h before restraint). These findings suggest that the development of gastric ulcers in cold-stressed mice may be linked with the enhancement of calcium/calmodulin-dependent catecholamine synthesis in the brain.
从大脑中钙/钙调蛋白依赖性多巴胺合成系统的角度，对小鼠胃应激性溃疡进行了研究。通过将小鼠置于4℃环境中进行约束来诱导冷应激。冷应激使血清和脑钙水平升高，并且发现脑钙水平升高会增强多巴胺合成，而脑多巴胺水平的相继升高会导致胃溃疡形成。腹腔注射EDTA（1微摩尔/小鼠，约束前1小时）或α-甲基酪氨酸（一种酪氨酸羟化酶抑制剂，100毫克/千克，约束前24小时）预处理可显著降低冷应激引起的胃溃疡发生率，而氯化钙（40微摩尔/千克，约束前1小时）预处理则会使其进一步显著增加。这些发现表明，冷应激小鼠胃溃疡的发生可能与大脑中钙/钙调蛋白依赖性儿茶酚胺合成的增强有关。
