潜在的抗病毒药物。第二部分。无环链取代的吡嗪酮的合成与抗病毒评估。
Potential antiviral agents. Part II. Synthesis and antiviral evaluation of pyrazinones substituted with acyclic chains.
作者信息
Davis J, Benhaddou R, Fedoryak O, Granet R, Krausz P, Bliard C, De Monte M, Aubertin A M
机构信息
Laboratoire de Chimie des Substances Naturelles, Université de Limoges, France.
出版信息
Nucleosides Nucleotides. 1998 Aug;17(8):1489-504. doi: 10.1080/07328319808003482.
PMID:9672706
Abstract
The synthesis of a series of 4'-substituted hydroxybutyl pyrazine analogues of the anti-herpes compound, acyclovir, is described. The compounds were characterized with 1H and 13C nmr, mass and IR spectroscopy. Antiviral (HSV-1, CMV, Cox B4, HIV-1) properties of these compounds were examined. None of these compounds were active against these viruses.
摘要
本文描述了一系列抗疱疹化合物阿昔洛韦的4'-取代羟基丁基吡嗪类似物的合成。通过¹H和¹³C核磁共振、质谱和红外光谱对这些化合物进行了表征。研究了这些化合物的抗病毒（单纯疱疹病毒1型、巨细胞病毒、柯萨奇B4病毒、人类免疫缺陷病毒1型）特性。这些化合物对这些病毒均无活性。
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