无环链取代的吡嗪酮的合成与抗病毒评估

Synthesis and antiviral evaluation of pyrazinones substituted with acyclic chains.

作者信息

Davis J, Benhaddou R, Granet R, Krausz P, Demonte M, Aubertin A M

机构信息

Laboratoire de Chimie des Substances Naturelles, Université de Limoges, France.

出版信息

Nucleosides Nucleotides. 1998 May;17(5):875-93. doi: 10.1080/07328319808003460.

DOI:10.1080/07328319808003460

PMID:9708329

Abstract

The synthesis of a series of pyrazine analogues of the anti-herpes compound, acyclovir is described. These syntheses were accomplished by various methods: in the presence of a Lewis acid or NaH for hydroxyethoxymethyl and hydroxybutyl groups or by sequential oxidation/reduction of 1-(beta-D-ribofuranosyl)-2-pyrazinones for 2',3'-acyclonucleosides. Antiviral (HSV-1, CMV, Cox B4, HIV-1) properties of these compounds were determined.

摘要

描述了一系列抗疱疹化合物阿昔洛韦的吡嗪类似物的合成。这些合成通过多种方法完成：在路易斯酸或氢化钠存在下用于羟乙氧基甲基和羟丁基基团，或通过对2',3'-无环核苷的1-(β-D-呋喃核糖基)-2-吡嗪酮进行连续氧化/还原。测定了这些化合物的抗病毒（单纯疱疹病毒1型、巨细胞病毒、柯萨奇B4病毒、人类免疫缺陷病毒1型）特性。