Crowley W R, Rodriguez-Sierra J F, Komisaruk B R
Neuroendocrinology. 1976;20(4):328-38. doi: 10.1159/000122499.
Lordosis was elecited in 49% of 87 hormonally untreated, hypophysectomized-ovariectomized (hypox-ovx) female rats in response to palpation of the flanks and perineum (vaginal stimulation was not applied). By contrast, only 12% of 113 hormonally untreated ovariectomized (ovx) rats showed lordosis in response to such stimulation. Subsequently, hypox-ovx and ovx-only rats were given daily injections of 1 mug/kg estradiol benzoate (EB) and tested for sexual receptivity with males. Teh estrogen-treated hypox-ovx females became sexually receptive significantly earlier, and exhibited higher lordosis quotients and more soliciting behavior, than the estrogen-treated ovx-only rats. The increased sexual responsiveness in the hypox-ovx rats could be due to increased LRH activity. To test this, we treated hypox-ovx rats with dihydrotestosterone propionate (DHT-P), which suppresses plasma LH levels but is relatively ineffective in inducing sexual receptivity, and found a significant depression of lordosis responsiveness. These experiments suggest that hypox-ovx females show a heightened responsiveness to hormonal and/or sensory factors that induce a lordosis response, possibly because of increased LRH activity.
在87只未经激素处理的垂体切除-卵巢切除（hypox-ovx）雌性大鼠中，49%在触摸胁腹和会阴（未进行阴道刺激）时出现脊柱前凸反应。相比之下，在113只未经激素处理的卵巢切除（ovx）大鼠中，只有12%在受到此类刺激时表现出脊柱前凸反应。随后，对hypox-ovx和仅ovx的大鼠每日注射1微克/千克苯甲酸雌二醇（EB），并与雄性大鼠进行性接受性测试。与仅接受雌激素处理的ovx大鼠相比，接受雌激素处理的hypox-ovx雌性大鼠性接受能力显著提前出现，且表现出更高的脊柱前凸商和更多的求偶行为。hypox-ovx大鼠性反应性增加可能是由于促黄体激素释放激素（LRH）活性增加所致。为了验证这一点，我们用丙酸双氢睾酮（DHT-P）处理hypox-ovx大鼠，该物质可抑制血浆促黄体生成素（LH）水平，但在诱导性接受能力方面相对无效，结果发现脊柱前凸反应性显著降低。这些实验表明，hypox-ovx雌性大鼠对诱导脊柱前凸反应的激素和/或感觉因素表现出更高的反应性，这可能是由于LRH活性增加所致。
