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1
Fab-independent antiadhesion effects of secretory immunoglobulin A on S-fimbriated Escherichia coli are mediated by sialyloligosaccharides.分泌型免疫球蛋白A对产S菌毛大肠杆菌的不依赖于Fab的抗黏附作用由唾液酸化低聚糖介导。
Infect Immun. 1998 Aug;66(8):3971-3. doi: 10.1128/IAI.66.8.3971-3973.1998.
2
Inhibition of adhesion of S-fimbriated Escherichia coli to buccal epithelial cells by human milk fat globule membrane components: a novel aspect of the protective function of mucins in the nonimmunoglobulin fraction.人乳脂肪球膜成分对S菌毛大肠杆菌黏附颊黏膜上皮细胞的抑制作用：黏蛋白在非免疫球蛋白部分保护功能的新方面
Infect Immun. 1992 Jul;60(7):2893-9. doi: 10.1128/iai.60.7.2893-2899.1992.
3
Binding characteristics of S fimbriated Escherichia coli to isolated brain microvascular endothelial cells.S 菌毛大肠杆菌与分离的脑微血管内皮细胞的结合特性
Am J Pathol. 1994 Nov;145(5):1228-36.
4
Basement membrane carbohydrate as a target for bacterial adhesion: binding of type I fimbriae of Salmonella enterica and Escherichia coli to laminin.作为细菌黏附靶点的基底膜碳水化合物：肠炎沙门氏菌和大肠杆菌I型菌毛与层粘连蛋白的结合
Mol Microbiol. 1993 Jan;7(2):229-37. doi: 10.1111/j.1365-2958.1993.tb01114.x.
5
Binding sites in the rat brain for Escherichia coli S fimbriae associated with neonatal meningitis.与新生儿脑膜炎相关的大肠杆菌S菌毛在大鼠脑中的结合位点。
J Clin Invest. 1988 Mar;81(3):860-5. doi: 10.1172/JCI113395.
6
Binding of milk oligosaccharides by several enterotoxigenic Escherichia coli strains isolated from calves.从犊牛分离出的几种产肠毒素大肠杆菌菌株对乳寡糖的结合作用。
Glycoconj J. 2002 Jan;19(1):5-11. doi: 10.1023/a:1022572628891.
7
Tamm-Horsfall protein inhibits binding of S- and P-fimbriated Escherichia coli to human renal tubular epithelial cells.Tamm-Horsfall蛋白可抑制S菌毛和P菌毛大肠杆菌与人肾小管上皮细胞的结合。
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8
Quantitative differences in adhesiveness of type 1 fimbriated Escherichia coli due to structural differences in fimH genes.由于fimH基因结构差异导致的1型菌毛大肠杆菌黏附性的定量差异。
J Bacteriol. 1995 Jul;177(13):3680-6. doi: 10.1128/jb.177.13.3680-3686.1995.
9
Binding of cloned S-fimbriated E. coli to human buccal epithelial cells--different inhibition of binding by neonatal saliva and adult saliva.克隆的S菌毛大肠杆菌与人颊上皮细胞的结合——新生儿唾液和成人唾液对结合的不同抑制作用
Zentralbl Bakteriol. 1991 Jan;274(4):514-8. doi: 10.1016/s0934-8840(11)80089-7.
10
Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin.分泌型免疫球蛋白A携带针对1型大肠杆菌菌毛凝集素的寡糖受体。
Infect Immun. 1990 Sep;58(9):3073-7. doi: 10.1128/iai.58.9.3073-3077.1990.

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Nasal delivery of secretory IgA confers enhanced neutralizing activity against Omicron variants compared to its IgG counterpart.与IgG相比，经鼻腔递送分泌型IgA对奥密克戎变体具有更强的中和活性。
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Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets.分泌型免疫球蛋白 A 的 N-聚糖有助于保护无菌仔猪免受大肠杆菌 O55 感染。
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Laetiporus sulphureus-fermented wheat bran enhanced the broiler growth performance by improving the intestinal microflora and inflammation status.硫磺菌发酵麦麸通过改善肠道微生物区系和炎症状态来提高肉鸡的生长性能。
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Human Milk Proteins and Their Glycosylation Exhibit Quantitative Dynamic Variations during Lactation.人乳蛋白质及其糖基化在哺乳期表现出定量动态变化。
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本文引用的文献

1
Specificity of S fimbriae on recombinant Escherichia coli: preferential binding to gangliosides expressing NeuGc alpha (2-3)Gal and NeuAc alpha (2-8)NeuAc.重组大肠杆菌上S菌毛的特异性：优先结合表达NeuGcα(2-3)Gal和NeuAcα(2-8)NeuAc的神经节苷脂。
Infect Immun. 1993 May;61(5):2108-15. doi: 10.1128/iai.61.5.2108-2115.1993.
2
Inhibition of adhesion of S-fimbriated E. coli to buccal epithelial cells by human skim milk is predominantly mediated by mucins and depends on the period of lactation.
Acta Paediatr. 1993 Jan;82(1):6-11. doi: 10.1111/j.1651-2227.1993.tb12505.x.
3
Occurrence and nature of bacterial IgA proteases.细菌IgA蛋白酶的发生与性质。
Ann N Y Acad Sci. 1983 Jun 30;409:612-24. doi: 10.1111/j.1749-6632.1983.tb26903.x.
4
Escherichia coli strains binding neuraminyl alpha 2-3 galactosides.
Biochem Biophys Res Commun. 1983 Mar 16;111(2):456-61. doi: 10.1016/0006-291x(83)90328-5.
5
Escherichia coli fimbriae recognizing sialyl galactosides.识别唾液酸半乳糖苷的大肠杆菌菌毛
J Bacteriol. 1984 Aug;159(2):762-6. doi: 10.1128/jb.159.2.762-766.1984.
6
Studies on human secretory immunoglobulin A. IV. Carbohydrate composition.人类分泌型免疫球蛋白A的研究。IV. 碳水化合物组成。
J Immunol. 1972 Jun;108(6):1631-6.
7
Glycopeptides of heavy chains from human IgA myeloma proteins.人IgA骨髓瘤蛋白重链的糖肽
J Immunol. 1974 May;112(5):1623-7.
8
Structure of the carbohydrate units of IgA1 immunoglobulin. I. Composition, glycopeptide isolation, and structure of the asparagine-linked oligosaccharide units.免疫球蛋白IgA1碳水化合物单位的结构。I. 天冬酰胺连接的寡糖单位的组成、糖肽分离及结构。
J Biol Chem. 1974 Nov 25;249(22):7260-9.
9
Immunoglobulin A (IgA).免疫球蛋白A（IgA）。
Methods Enzymol. 1985;116:37-75. doi: 10.1016/s0076-6879(85)16005-2.
10
Primary structure of twenty three neutral and monosialylated oligosaccharides O-glycosidically linked to the human secretory immunoglobulin A hinge region determined by a combination of permethylation analysis and 400-MHz 1H-NMR spectroscopy.通过全甲基化分析和400兆赫兹氢核磁共振光谱相结合的方法确定了与人类分泌型免疫球蛋白A铰链区O-糖苷键连接的23种中性和单唾液酸化寡糖的一级结构。
Eur J Biochem. 1989 Jun 15;182(2):457-76. doi: 10.1111/j.1432-1033.1989.tb14853.x.

分泌型免疫球蛋白A对产S菌毛大肠杆菌的不依赖于Fab的抗黏附作用由唾液酸化低聚糖介导。

Fab-independent antiadhesion effects of secretory immunoglobulin A on S-fimbriated Escherichia coli are mediated by sialyloligosaccharides.

作者信息

Schroten H, Stapper C, Plogmann R, Köhler H, Hacker J, Hanisch F G

机构信息

Zentrum für Kinderheilkunde der Heinrich-Heine-Universität, Düsseldorf, Germany.

出版信息

Infect Immun. 1998 Aug;66(8):3971-3. doi: 10.1128/IAI.66.8.3971-3973.1998.

DOI:10.1128/IAI.66.8.3971-3973.1998
PMID:9673289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC108467/
Abstract

S-fimbriated Escherichia coli strains cause sepsis and meningitis in newborns and are known to recognize the carbohydrate sequence sialyl-(alpha2-3)-galactoside. We show that adhesion of cloned S-fimbriated E. coli to human epithelial cells is inhibited Fab independently by sialyloligosaccharides on secretory immunoglobulin A (s-IgA). This indicates an anti-infective function of s-IgA (Fc), particularly in early human milk.

摘要

产S菌毛的大肠杆菌菌株可导致新生儿败血症和脑膜炎，已知该菌株可识别碳水化合物序列唾液酸基-（α2-3）-半乳糖苷。我们发现，分泌型免疫球蛋白A（s-IgA）上的唾液酸寡糖可独立地通过Fab抑制克隆的产S菌毛大肠杆菌与人上皮细胞的黏附。这表明s-IgA（Fc）具有抗感染功能，尤其是在初乳中。