Greco A V, Ghirlanda G, Fedeli G, Rebuzzi A, Altomonte L, Manna R
Minerva Med. 1976 Oct 6;67(47):3027-32.
A 500 mg L-Dopa administration in normal and cirrhotic subjects does not determinate a significant varation of plasma glucose and insulin level, while a peak plasma GH level in both cirrhotic and normal subjects occurred at 90' with a significantly greates values in cirrhotics. It is doubtful to affirm that a high plasma GH level is the only one factor which responsable of glucose intolerance in cirrhotic subjects, when there are many others factors contribute to it in synergic way. In order to elucidate the hypothesis on possible pathogenetic mechanism it is discussed some of our own experience and observations.
在正常受试者和肝硬化受试者中给予500毫克左旋多巴，不会导致血浆葡萄糖和胰岛素水平出现显著变化，而肝硬化受试者和正常受试者的血浆生长激素（GH）水平峰值均出现在90分钟时，且肝硬化患者的值明显更高。当有许多其他因素以协同方式促成肝硬化患者的葡萄糖不耐受时，断言高血浆GH水平是导致肝硬化患者葡萄糖不耐受的唯一因素是值得怀疑的。为了阐明关于可能致病机制的假设，本文讨论了我们自己的一些经验和观察结果。
