[药物性帕金森综合征。与帕金森病相比的临床方面]
[Drug-induced parkinsonism. Clinical aspects compared with Parkinson disease].
作者信息
Errea-Abad J M, Ara-Callizo J R, Aibar-Remón C
机构信息
Servicio de Neurología, Hospital Comarcal de Barbastro, Huesca.
出版信息
Rev Neurol. 1998 Jul;27(155):35-9.
INTRODUCTION
Drug-induced Parkinsonism (DIP) is the second commonest cause of Parkinson syndrome, after Parkinson disease (PD) and represents between 10% and 30% of all patients with Parkinsonism.
OBJECTIVES
To study the frequency and drugs responsible for DIP and to compare some of the clinical characteristics of these patients and those with PD.
PATIENTS AND METHODS
A retrospective community based study in Bajo Aragon district to determine the frequency of PD and other Parkinsonism, including DIP. PD was diagnosed on the criteria proposed by the United Kingdom Parkinson's Disease Society Brain Bank and DIP on the criteria of Jiménez et al.
RESULTS
Calcium antagonists were the cause of 73% of the DIP, followed by neuroleptic drugs (11.5%). There were 73% women (19/26). The patients with DIP were older than those with PD when their symptoms started (p = 0.02). In patients with DIP, 48% presented with bilateral symptoms as compared with 7% in PD (p < 0.0001).
CONCLUSIONS
- Cinarizine is the main drug responsible for DIP (58%) 2. As compared with patients with PD, patients with DIP are mainly women, older, more frequently have bilateral onset of symptoms and consult the doctor sooner.
引言
药物性帕金森综合征（DIP）是帕金森综合征的第二大常见病因，仅次于帕金森病（PD），占所有帕金森综合征患者的10%至30%。
目的
研究DIP的发生频率及相关药物，并比较这些患者与PD患者的一些临床特征。
患者与方法
在阿拉贡下区进行一项基于社区的回顾性研究，以确定PD及其他帕金森综合征（包括DIP）的发生频率。PD根据英国帕金森病协会脑库提出的标准进行诊断，DIP根据希门尼斯等人的标准进行诊断。
结果
钙拮抗剂是73%的DIP的病因，其次是抗精神病药物（11.5%）。女性占73%（19/26）。DIP患者症状开始时的年龄比PD患者大（p = 0.02）。DIP患者中，48%出现双侧症状，而PD患者中这一比例为7%（p < 0.0001）。
结论
- 桂利嗪是导致DIP的主要药物（58%）。2. 与PD患者相比，DIP患者主要为女性，年龄较大，症状双侧起病更为频繁，且就医较早。
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