Negrotti A, Calzetti S, Sasso E
Istituto di Neurologia, Università di Parma, Italy.
Neurotoxicology. 1992 Spring;13(1):261-4.
The risk of developing drug-induced parkinsonism (DIP) has been related to a number of factors but it remains up to now poorly defined. The aim of this survey has been to evaluate retrospectively the possible role of inherited components in 25 patients with parkinsonism induced by chronic exposure to the calcium-entry blockers cinnarizine and flunarizine. The finding of higher occurrence of a positive family history for Parkinson's disease (PD) and/or essential tremor (ET) and of higher frequency of secondary cases with PD and/or ET among close relatives of the patients as compared to age-matched controls, suggests the involvement of genetic susceptibility in developing this drug-induced disorder. DIP could be regarded as a multifactorial disease process resulting from potential neurotoxicity of drugs on a background of inherited predisposition.
药物性帕金森综合征（DIP）的发病风险与多种因素有关，但迄今为止仍定义不清。本调查旨在回顾性评估25例因长期接触钙通道阻滞剂桂利嗪和氟桂利嗪而诱发帕金森综合征的患者中遗传因素可能发挥的作用。与年龄匹配的对照组相比，这些患者帕金森病（PD）和/或特发性震颤（ET）的家族史阳性发生率更高，且其近亲中PD和/或ET的继发病例频率更高，这表明遗传易感性参与了这种药物诱发疾病的发生。DIP可被视为在遗传易感性背景下，药物潜在神经毒性导致的多因素疾病过程。
