Martí-Massó J F, Poza J J
Department of Neurology, Hospital Ntra. Sra. Aránzazu, San Sebastián, Basque Country, Spain.
Mov Disord. 1998 May;13(3):453-6. doi: 10.1002/mds.870130313.
A retrospective study was carried out to investigate the evolution of patients diagnosed with cinnarizine-induced parkinsonism (CIP) over the past 15 years. A total of 74 cases of CIP were found among 172 patients with drug-induced parkinsonism (DIP). Both CIP and other DIP were significantly more frequent in women. No clinical differences between CIP and other DIP were found. Most of the patients (66 of 74) completely recovered after cinnarizine withdrawal in 1-16 months. Eleven patients later developed Parkinson's disease; four of them had previously recovered. Five patients had tardive dyskinesia. CIP accounts for a high proportion of DIP referred to neurologists in populations in which cinnarizine is widely prescribed. The symptoms typically resolve after drug withdrawal, although complete recovery may take more than 1 year.
开展了一项回顾性研究，以调查过去15年中被诊断为桂利嗪诱发帕金森症（CIP）患者的病情演变。在172例药物性帕金森症（DIP）患者中，共发现74例CIP。CIP和其他DIP在女性中均更为常见。未发现CIP与其他DIP之间存在临床差异。大多数患者（74例中的66例）在停用桂利嗪后的1至16个月内完全康复。11例患者后来患上帕金森病；其中4例此前已康复。5例患者出现迟发性运动障碍。在桂利嗪广泛处方的人群中，转诊至神经科医生的DIP中，CIP占比很高。停药后症状通常会缓解，不过完全康复可能需要1年以上时间。
