髓鞘相关糖蛋白（MAG）和髓鞘少突胶质细胞糖蛋白（MOG）可促进胚胎小鼠脊髓神经元的轴突生长。

MAG and MOG enhance neurite outgrowth of embryonic mouse spinal cord neurons.

作者信息

Turnley A M, Bartlett P F

机构信息

Development and Neurobiology Group, The Walter and Eliza Hall Institute of Medical Research, P.O. Royal Melbourne Hospital, Victoria, Australia.

出版信息

Neuroreport. 1998 Jun 22;9(9):1987-90. doi: 10.1097/00001756-199806220-00013.

DOI:10.1097/00001756-199806220-00013

PMID:9674579

Abstract

Myelin-associated glycoprotein (MAG) inhibits neurite outgrowth of postnatal spinal cord neurons, but its effect on embryonic neurons is unknown. The effect on neurite outgrowth of another myelin protein, myelin-oligodendrocyte glycoprotein (MOG) is also unknown. We determined the effect of MAG and MOG on embryonic day 17 spinal cord neurons, which were cultured on MAG, MOG or control transfected CHO cells. Neurite outgrowth was examined and both total neurite length and longest neurite length were significantly enhanced by both MAG and MOG. These findings show that, in contrast to postnatal spinal cord neurons, MAG can enhance neurite outgrowth of embryonic spinal cord neurons. In addition, another myelin protein, MOG, can also modulate neurite outgrowth.

摘要

髓鞘相关糖蛋白（MAG）可抑制出生后脊髓神经元的轴突生长，但其对胚胎神经元的影响尚不清楚。另一种髓磷脂蛋白，即髓鞘少突胶质细胞糖蛋白（MOG）对轴突生长的影响也不清楚。我们测定了MAG和MOG对胚胎第17天脊髓神经元的影响，这些神经元在转染了MAG、MOG或对照的CHO细胞上培养。检测轴突生长情况，发现MAG和MOG均能显著增加总轴突长度和最长轴突长度。这些发现表明，与出生后脊髓神经元不同，MAG可促进胚胎脊髓神经元的轴突生长。此外，另一种髓磷脂蛋白MOG也能调节轴突生长。