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在大鼠体内,同时给予D-青霉胺和锌在促进铜排泄方面并不比单独使用这两种药物中的任何一种更具优势。

Concurrent administration of D-penicillamine and zinc has no advantages over the use of either single agent on copper excretion in the rat.

作者信息

Domingo J L, Gómez M, Jones M M

机构信息

Laboratory of Toxicology and Environmental Health, School of Medicine, Rovira i Virgili University, Reus, Spain.

出版信息

Toxicology. 1998 Apr 3;126(3):195-201. doi: 10.1016/s0300-483x(98)00017-1.

Abstract

The present study was conducted to examine in rats whether the combined use of D-penicillamine (DPA) and a zinc salt, or the administration of a DPA/Zn complex could have some advantages over the use of either single agent on the excretion of copper. In a first experiment, three groups of adult male Sprague Dawley rats were given by gavage one of the following treatments for 5 days: 0.5 mmol/kg/day of DPA, 0.046 mmol/kg/day of zinc acetate dihydrate, and 0.5 mmol/kg/day of DPA plus 0.046 mmol/kg/day of zinc acetate dihydrate. A fourth group of rats (control group) received deionized water during the same period. An increase in the urinary excretion of copper was observed following DPA treatment, which continued for at least 5 days after the administration of this compound was stopped. The amount of copper present in the feces, including that in the diet, was approximately 60 times greater than that normally present in control urines. During the period of zinc acetate administration, the amount of copper in the feces was slightly, but significantly greater than that during control, D-penicillamine, or D-penicillamine plus zinc acetate administration. No differences between the treated groups and the control group were found in brain, liver, kidney and spleen concentrations of rats 5 days after the end of the treatment period. In a second experiment, a similar comparison between D-penicillamine and sodium bis(3-mercapto-D-valinato)zinc hexahydrate (Na2[Zn(DPA)2] x 6H2O), both given by gavage, also showed no significant differences in the urinary excretion of copper in rats.

摘要

本研究旨在探讨在大鼠中,D-青霉胺(DPA)与锌盐联合使用,或给予DPA/锌复合物,在铜排泄方面是否比单独使用任何一种药物具有某些优势。在第一个实验中,三组成年雄性Sprague Dawley大鼠经口灌胃给予以下处理之一,持续5天:0.5 mmol/kg/天的DPA、0.046 mmol/kg/天的二水合醋酸锌,以及0.5 mmol/kg/天的DPA加0.046 mmol/kg/天的二水合醋酸锌。第四组大鼠(对照组)在同一时期接受去离子水。DPA处理后观察到尿铜排泄增加,在停止给予该化合物后至少持续5天。粪便中铜的含量,包括饮食中的铜,比正常对照尿液中的含量大约高60倍。在给予醋酸锌期间,粪便中的铜含量略高于对照组、D-青霉胺组或D-青霉胺加醋酸锌组,但差异显著。在治疗期结束5天后,各治疗组与对照组大鼠的脑、肝、肾和脾中的铜浓度没有差异。在第二个实验中,同样经口灌胃给予D-青霉胺和六水合双(3-巯基-D-缬氨酸根)锌钠(Na2[Zn(DPA)2]·6H2O)进行类似比较,结果也显示大鼠尿铜排泄没有显著差异。

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