Ho A K, Bradshaw J L, Cunnington R, Phillips J G, Iansek R
Psychology Department, Monash University, Clayton, Victoria, 3168, Australia.
Brain Lang. 1998 Aug;64(1):122-45. doi: 10.1006/brln.1998.1959.
Parkinson's disease (PD) is a neurodegenerative movement disorder primarily due to basal ganglia dysfunction. While much research has been conducted on Parkinsonian deficits in the traditional arena of musculoskeletal limb movement, research in other functional motor tasks is lacking. The present study examined articulation in PD with increasingly complex sequences of articulatory movement. Of interest was whether dysfunction would affect articulation in the same manner as in limb-movement impairment. In particular, since very similar (homogeneous) articulatory sequences (the tongue twister effect) are more difficult for healthy individuals to achieve than dissimilar (heterogeneous) gestures, while the reverse may apply for skeletal movements in PD, we asked which factor would dominate when PD patients articulated various grades of artificial tongue twisters: the influence of disease or a possible difference between the two motor systems. Execution was especially impaired when articulation involved a sequence of motor program heterogeneous in terms of place of articulation. The results are suggestive of a hypokinesic tendency in complex sequential articulatory movement as in limb movement. It appears that PD patients do show abnormalities in articulatory movement which are similar to those of the musculoskeletal system. The present study suggests that an underlying disease effect modulates movement impairment across different functional motor systems.
帕金森病（PD）是一种主要由基底神经节功能障碍引起的神经退行性运动障碍。虽然在传统的肌肉骨骼肢体运动领域已经对帕金森病的缺陷进行了大量研究，但在其他功能性运动任务方面的研究却很缺乏。本研究通过越来越复杂的发音运动序列来检查帕金森病患者的发音情况。令人感兴趣的是，功能障碍是否会以与肢体运动障碍相同的方式影响发音。特别是，由于非常相似（同质）的发音序列（绕口令效应）对健康个体来说比不相似（异质）的手势更难完成，而在帕金森病中骨骼运动可能情况相反，我们探究当帕金森病患者说出不同难度等级的人工绕口令时，哪个因素会占主导：疾病的影响还是两个运动系统之间可能存在的差异。当发音涉及到在发音位置方面异质的运动程序序列时，执行能力尤其受损。结果表明，在复杂的连续发音运动中存在运动减少倾向，就像在肢体运动中一样。似乎帕金森病患者在发音运动中确实表现出与肌肉骨骼系统类似的异常。本研究表明，潜在的疾病效应会调节不同功能性运动系统中的运动障碍。
