基因肥胖（ob/ob）小鼠大脑自主调节中枢中c-fos表达的改变。

Altered c-fos expression in autonomic regulatory centers of genetically obese (ob/ob) mouse brain.

作者信息

Huang X F, Wang H

机构信息

Metabolic Research Center, Department of Biomedical Science, University of Wollongong, Wollongong, NSW 2522, Australia.

出版信息

Brain Res. 1998 Jul 20;799(2):307-10. doi: 10.1016/s0006-8993(98)00541-1.

DOI:10.1016/s0006-8993(98)00541-1

PMID:9675321

Abstract

This study examined c-fos-like immunoreactivity (FLI) in the brain of obese (ob/ob) and lean (+/+) mice during states of satiety and hunger. The results demonstrated that there is an altered neural activity primarily in the hypothalamus of the obese mouse brain. Most interestingly, only obese mice had an increased FLI in the dorsomedial and supramammillary nuclei. Conversely, only lean mice showed increase in FLI in the medial part of perifornical nucleus following food deprivation for 24 h.

摘要

本研究检测了饱足和饥饿状态下肥胖（ob/ob）小鼠和瘦型（+/+）小鼠大脑中的c-fos样免疫反应性（FLI）。结果表明，肥胖小鼠大脑中主要是下丘脑的神经活动发生了改变。最有趣的是，只有肥胖小鼠的背内侧核和乳头体上核中的FLI增加。相反，仅在禁食24小时后，瘦型小鼠穹窿周核内侧部分的FLI才出现增加。