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通过冷冻电子显微镜观察到的阳离子脂质 - DNA 复合物中三维层间相关性的证据。

Evidence for three-dimensional interlayer correlations in cationic lipid-DNA complexes as observed by cryo-electron microscopy.

作者信息

Battersby B J, Grimm R, Huebner S, Cevc G

机构信息

Medizinische Biophysik, Technische Universität München, Klinikum r. d.I., Ismaningerstr. 22, D-81675 Munich, Germany.

出版信息

Biochim Biophys Acta. 1998 Jul 17;1372(2):379-83. doi: 10.1016/s0005-2736(98)00062-5.

DOI:10.1016/s0005-2736(98)00062-5
PMID:9675338
Abstract

A fingerprint-like pattern across multilamellar, lipid-DNA complexes is attributed to DNA condensed as parallel helices between lipid bilayers. It is argued that the patterning indicates the existence of 3-D correlation forces between DNA-covered bilayers, following the DNA-driven formation of multilamellar liposomes from unilamellar vesicles.

摘要

多层脂质 - DNA 复合物上类似指纹的图案归因于在脂质双层之间以平行螺旋形式凝聚的 DNA。有人认为，这种图案表明在 DNA 驱动单层囊泡形成多层脂质体之后，被 DNA 覆盖的双层之间存在三维相关力。

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