Martín Esteban M, Pascual C Y, García Ara M C
Servicio de Alergia, Hospital Universitario Infantil La Paz, Madrid.
Allergol Immunopathol (Madr). 1998 May-Jun;26(3):97-101.
The occurrence of allergic diseases depends on genetic and environmental factors. Genetic factors determine individual risk and these persons should undergo early detection. However, the methods currently available (mainly clinical history and IgE in umbilical cord blood) have poor predictive value so their use in the general population is not practical. In contrast, the feeding habits of newborns and infants can influence the development of food allergies in children at risk. Therefore, several modes of action have been proposed, based mainly on prolonging breast-feeding (with the mother avoiding allergenic foods) and delaying the introduction of complementary foods considered to be a risk. Use of cow milk protein hydrolysates may have a preventive effect similar to that of breast-feeding, but their administration is not problem-free. The preventive effect of partial hydrolysates or soybean formulas is even more questionable.
过敏性疾病的发生取决于遗传和环境因素。遗传因素决定个体风险,这些人应进行早期检测。然而,目前可用的方法(主要是临床病史和脐带血中的IgE)预测价值较差,因此在普通人群中使用并不实际。相比之下,新生儿和婴儿的喂养习惯会影响有风险儿童食物过敏的发展。因此,已经提出了几种作用方式,主要基于延长母乳喂养(母亲避免食用致敏食物)以及推迟引入被认为有风险的辅食。使用牛奶蛋白水解物可能具有与母乳喂养类似的预防效果,但其给药并非毫无问题。部分水解物或大豆配方奶粉的预防效果更值得怀疑。