De Clercq E
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Intervirology. 1997;40(5-6):295-303. doi: 10.1159/000150563.
The acyclic nucleoside phosphonates [HPMPC (cidofovir), PMEA (adefovir) and PMPA] have proved to the effective in vitro (cell culture systems) and in vivo (animal models, clinical studies) against a wide variety of DNA virus and retrovirus infections: i.e., HPMPC against herpesvirus (herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus types 6, 7, and 18), polyoma-, papilloma-, adeno-, and poxvirus (vaccinia virus, molluscum contagiosum virus) infections; PMEA against herpesvirus, hepadnavirus (human hepatitis B virus) and retrovirus (human immunodeficiency virus type 1 and 2, simian immunodeficiency virus, and feline immunodeficiency virus) infections; and PMPA against both hepadna- and retrovirus infections.
无环核苷膦酸酯类药物[HPMPC（西多福韦）、PMEA（阿德福韦）和PMPA]已被证明在体外（细胞培养系统）和体内（动物模型、临床研究）对多种DNA病毒和逆转录病毒感染有效：即HPMPC对疱疹病毒（1型和2型单纯疱疹病毒、水痘带状疱疹病毒、巨细胞病毒、爱泼斯坦-巴尔病毒、6型、7型和18型人类疱疹病毒）、多瘤病毒、乳头瘤病毒、腺病毒和痘病毒（痘苗病毒、传染性软疣病毒）感染有效；PMEA对疱疹病毒、嗜肝DNA病毒（人类乙型肝炎病毒）和逆转录病毒（1型和2型人类免疫缺陷病毒、猿猴免疫缺陷病毒和猫免疫缺陷病毒）感染有效；PMPA对嗜肝DNA病毒和逆转录病毒感染均有效。
