Cacopardo B, Nigro L, Celesia B M, Minniti S, Brancati G, Montineri A, Nunnari A
Institute of Infectious Diseases, University of Catania, Italy.
Ital J Gastroenterol Hepatol. 1998 Apr;30(2):162-6.
Clinical variability in the natural course of cryptosporidiosis in patients affected by acquired immunodeficiency syndrome has been correlated to the degree of T-cell immunosuppression; however, cryptosporidiosis can occur as a self-limiting disease even in patients with very low T-lymphocyte count.
We tested the serum values of a panel of cytokines in AIDS patients with cryptosporidial enteritis in order to evaluate their role in predicting the clinical outcome of the disease.
Thirty one HIV-positive patients with cryptosporidiosis and a CD4+ count of less than 100/mm3 were studied. Interleukin-2, Interleukin-4, Interleukin-10, Interferon-gamma, Interleukin-12, Tumor Necrosis Factor alpha values were measured in serum at diagnosis.
Interleukin-4 and Interleukin-10 concentration was significantly lower in patients with mild disease whereas serum Interleukin-2 and -12 was higher in this same group. The serum level of Interferon-gamma did not differ in relation to the severity of the disease. Patients with self-limiting diarrhoea showed significantly lower levels of Tumor Necrosis Factor-alpha than subjects who did not show any clinical improvement.
In our study, it has been shown that cytokine levels in serum may represent early predictive markers both for the severity of symptoms and the clinical outcome of cryptosporidial enteritis in AIDS patients with a low CD4+ count.
获得性免疫缺陷综合征患者隐孢子虫病自然病程中的临床变异性与T细胞免疫抑制程度相关；然而，即使在T淋巴细胞计数非常低的患者中，隐孢子虫病也可能表现为自限性疾病。
我们检测了患有隐孢子虫性肠炎的艾滋病患者一组细胞因子的血清值，以评估它们在预测疾病临床结局中的作用。
研究了31例HIV阳性且患有隐孢子虫病、CD4 + 计数低于100/mm³的患者。在诊断时测量血清中的白细胞介素-2、白细胞介素-4、白细胞介素-10、干扰素-γ、白细胞介素-12、肿瘤坏死因子α值。
病情较轻的患者白细胞介素-4和白细胞介素-10浓度显著较低，而同一组患者血清白细胞介素-2和-12较高。干扰素-γ的血清水平与疾病严重程度无关。自限性腹泻患者的肿瘤坏死因子-α水平显著低于未显示任何临床改善的患者。
在我们的研究中，已表明血清中的细胞因子水平可能是CD4 + 计数低的艾滋病患者隐孢子虫性肠炎症状严重程度和临床结局的早期预测标志物。
