Charasse C, Boulahrouz R, Le Moal S, Bousser J, Pasquiou A, Le Cacheux P, Ang K S, Simon P, Ramée M P
Service de néphrologie, CHG, La Beauchée, St-Brieuc.
Nephrologie. 1998;19(4):211-5.
We report a case of intravascular malignant lymphomatosis observed in a 71 year-old male and characterised by the presence of a proteinuria in relation to the specific intraglomerular localisation. This malignant lymphoma, usually of the B phenotype, is rare and affects predominantly the central nervous system and the skin. Neoplastic cells home selectively to endothelium. Histological renal infiltration is frequent but a glomerular localisation, with proteinuria, is rare. The mechanism whereby lymphocytes home to endothelium cells is unclear but it could be related to the expression of lymphocyte-endothelium adhesion molecules. When present the nephrotic syndrome is associated with minimal change disease.
我们报告了一例在一名71岁男性中观察到的血管内恶性淋巴瘤，其特征为与肾小球内特定定位相关的蛋白尿。这种恶性淋巴瘤通常为B表型，较为罕见，主要影响中枢神经系统和皮肤。肿瘤细胞选择性地归巢于内皮细胞。肾脏的组织学浸润很常见，但伴有蛋白尿的肾小球定位则很罕见。淋巴细胞归巢于内皮细胞的机制尚不清楚，但可能与淋巴细胞 - 内皮细胞黏附分子的表达有关。当出现肾病综合征时，与微小病变性肾病相关。
