Jourdan Florence, Gurdjian Levone, Debure Alain, Brière Josette, Janin Anne, Droz Dominique
Service de Pathologie, hôpital Saint-Louis, AP-HP, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, France.
Ann Pathol. 2002 Jun;22(3):222-5.
We report the case of an intravascular large B-cell lymphoma in a 49-year-old woman, which was revealed by proteinuria. This type of lymphoma is very rare and corresponds to the proliferation of malignant lymphoid cells within the lumina of small vessels, resulting in ischemic lesions involving mainly brain and skin. Renal involvement is quite rare and remains asymptomatic, being discovered at autopsy. In this case, the renal biopsy demonstrated the presence of large malignant B cells in the glomerular lumina, associated with minimal glomerular damage. The mechanisms of the proteinuria occurring during intravascular lymphoma remain to elucidate.
我们报告了一例49岁女性的血管内大B细胞淋巴瘤，该病例由蛋白尿发现。这种类型的淋巴瘤非常罕见，是由小血管腔内恶性淋巴细胞增殖引起的，主要导致脑和皮肤的缺血性病变。肾脏受累相当罕见且无症状，多在尸检时发现。在该病例中，肾活检显示肾小球腔内存在大的恶性B细胞，伴有轻微的肾小球损伤。血管内淋巴瘤期间发生蛋白尿的机制仍有待阐明。
